Ceramide glucosyltransferase

From Wikipedia, the free encyclopedia
Ceramide glucosyltransferase
Identifiers
EC no.2.4.1.80
CAS no.37237-44-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Ceramide glucosyltransferase (or glucosylceramide synthase) is a glucosyltransferase enzyme involved in the production of glucocerebroside.[1]

It is classified under EC 2.4.1.80.

It is inhibited by miglustat and eliglustat, both drugs developed for the treatment of Gaucher disease.[citation needed]

See also[edit]

References[edit]

  1. ^ Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (May 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4638–43. doi:10.1073/pnas.93.10.4638. PMC 39331. PMID 8643456.

External links[edit]