SC 389 begins at an intersection with SC 39 (West Railroad Avenue/Festival Trail Road) in Perry, within Aiken County. It travels to the southeast, enters Orangeburg County, and intersects SC 394 (Salley Road) at a point northeast of Salley. Less than one mile (1.6 km) later, it intersects SC 3 (Capital Way). The highway continues to the southeast and enters the city limits of Neeses. It curves to the east-northeast and crosses over railroad tracks before meeting its eastern terminus, an intersection with U.S. Route 321 (US 321; Savannah Highway). Here, the roadway continues as Ninety Six Road.[3]