Camila Osorio defeated Tamara Zidanšek in the final, 5–7, 6–3, 6–4 to win the singles tennis title at the 2021 Copa Colsanitas. It was the Colombian teenage wildcard's first WTA Tour singles title. Ranked No. 180, Osorio became the lowest-ranked WTA title holder since world No. 299 Margarita Gasparyan at the 2018 Tashkent Open. Zidanšek was also in contention for her first WTA title.[1]
Bold denotes the mandatory tournaments (WTA 1000) † – Tournaments are affected by the COVID-19 pandemic * – Tournaments are introduced due to the impact of the COVID-19 pandemic