6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide

6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide
Identifiers
	IUPAC name 6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide;
CAS Number	1384929-25-2 ;
PubChem CID	57515146;
UNII	2BY259EY9C;
Chemical and physical data
Formula	C16H16ClN3O2
Molar mass	317.77 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c3cccnc3NC(=O)N(c1cc2Cl)CCc1cc2OCC;

6-Chloro-5-ethoxy-N-(pyridin-2-yl)indoline-1-carboxamide (CEPC) is a drug which acts as a potent and selective antagonist for the serotonin 5-HT_2C receptor. In animal studies it was found to potentiate the conditioned place preference induced by low-dose amphetamine, demonstrating that 5-HT_2C-mediated disinhibition of dopamine release can cause interactions with dopaminergic drugs.^[1]

References

^ McCorvy JD, Harland AA, Maglathlin R, Nichols DE (November 2011). "A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference". Neuroscience Letters. 505 (1): 10–3. doi:10.1016/j.neulet.2011.07.036. PMC 3213641. PMID 21827831.

[1] McCorvy JD, Harland AA, Maglathlin R, Nichols DE (November 2011). "A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference". Neuroscience Letters. 505 (1): 10–3. doi:10.1016/j.neulet.2011.07.036. PMC 3213641. PMID 21827831.

[1]

See also

References