ATP11C

ATP11C
Identifiers
Aliases	ATP11C, ATPIG, ATPIQ, ATPase phospholipid transporting 11C, HACXL
External IDs	OMIM: 300516; MGI: 1859661; HomoloGene: 27862; GeneCards: ATP11C; OMA:ATP11C - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	139,945,276 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	59,636,304 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; Achilles tendon; ; testicle; ; gonad; ; tail of epididymis; ; liver; ; parietal pleura; ; superficial temporal artery; ; visceral pleura; ; right lobe of liver;
	Top expressed in
	liver; ; secondary oocyte; ; ganglionic eminence; ; ventricular zone; ; granulocyte; ; tail of embryo; ; uterus; ; primary oocyte; ; thymus; ; choroid plexus of fourth ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; metal ion binding; protein binding; hydrolase activity; ATP binding; magnesium ion binding; ATPase-coupled intramembrane lipid transporter activity;
Cellular component	integral component of membrane; recycling endosome; endoplasmic reticulum membrane; membrane; plasma membrane; lysosomal membrane; endoplasmic reticulum; trans-Golgi network;
Biological process	pre-B cell differentiation; lipid transport; positive regulation of B cell differentiation; phospholipid transport; ion transmembrane transport; phospholipid translocation; transport;
	Sources:Amigo / QuickGO
Orthologs
	286410
	320940
	ENSG00000101974
	ENSMUSG00000062949
	Q8NB49
	Q9QZW0
	NM_001010986; NM_173694; NM_001353810; NM_001353811; NM_001353812
	NM_001001798; NM_001037863; NM_001359002
	NP_001010986; NP_775965; NP_001340739; NP_001340740; NP_001340741
	NP_001001798; NP_001032952; NP_001345931
	Wikidata
View/Edit Human	View/Edit Mouse

ATP11C is an enzyme that in humans is encoded by the ATP11C gene.

Function

ATP11C encodes a member of the Type IV P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of B cells and red blood cells,^[5]^[6] and for the prevention of intrahepatic cholestasis.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101974 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062949 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–40. doi:10.1038/ni.2012. PMC 3079768. PMID 21423172.
^ Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011). "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 (5): 441–9. doi:10.1038/ni.2011. PMC 3272780. PMID 21423173.
^ Siggs OM, Schnabl B, Webb B, Beutler B (May 2011). "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 7890–5. Bibcode:2011PNAS..108.7890S. doi:10.1073/pnas.1104631108. PMC 3093471. PMID 21518881.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101974 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062949 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid21423172-5] Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–40. doi:10.1038/ni.2012. PMC 3079768. PMID 21423172.

[pmid21423173-6] Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011). "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 (5): 441–9. doi:10.1038/ni.2011. PMC 3272780. PMID 21423173.

[pmid21518881-7] Siggs OM, Schnabl B, Webb B, Beutler B (May 2011). "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 7890–5. Bibcode:2011PNAS..108.7890S. doi:10.1073/pnas.1104631108. PMC 3093471. PMID 21518881.

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