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Andrew Oates

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Professor
Andrew Oates
Andy Oates in 2020
Born1969 (age 54–55)
Adelaide, Australia
CitizenshipAustralian
British
OccupationFull Professor
Known forSegmentation of the zebrafish body axis by the genetic oscillations
Academic background
EducationBiology
Alma materUniversity of Adelaide
University of Melbourne
Doctoral advisorAndrew F Wilks
Other advisorsRobert Ho
Academic work
DisciplineBiology
Sub-disciplineEmbryology
InstitutionsEPFL (École Polytechnique Fédérale de Lausanne)
Main interestsDevelopmental biology
Genetic oscillations
Biophysics
Embryology
Synchronization
Websitehttps://www.epfl.ch/labs/oateslab/

Andrew 'Andy' Charles Oates (born 1969 in Adelaide, Australia) is an Australian and British developmental biologist and embryologist specialized in biological pattern formation. He is professor at EPFL (École Polytechnique Fédérale de Lausanne) and head of the Segmentation Timing and Dynamics Laboratory at EPFL's School of Life Sciences.[1][2][3] Since 2021, he has been dean of EPFL's School of Life Sciences.[4]

Career

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Oates received an undergraduate degree in biochemistry with honors for his work at the Robert Saint's laboratory at the University of Adelaide in 1992. He then joined Andrew F. Wilks at the Ludwig Institute for Cancer Research and at the University of Melbourne as PhD student, and graduated in 1998.[5] His postdoctoral time was at the laboratory of Robert Ho both at Princeton University and at University of Chicago, where he began his studies on the segmentation clock in zebrafish.[6] In 2003, he moved to the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden to start his research group.[7][8] In 2012, he became professor of vertebrate developmental genetics at University College London and moved his group to the National Institute for Medical Research at Mill Hill in London.[9] In April 2015, he became a member of the Francis Crick Institute in London.[10]

In 2016, he joined EPFL as a full professor, where he is the founder and director of the Timing, Oscillation, Patterns Laboratory at EPFL's School of Life Sciences.[1][2][3]

Since 2018, he has served as director of the EPFL's Institute of Bioengineering,[11] and since January 2021 he has been the dean of the EPFL's School of Life Sciences.[4]

Research

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Oates' research laboratory is composed of biologists, engineers, and physicists. It draws on molecular genetics, quantitative imaging, and theoretical analysis in order to investigate populations of coupled genetic oscillators in vertebrate embryos, termed as segmentation clocks.[12] These systems drive the rhythmic, sequential, and precise formation of embryonic body segments, exhibiting rich spatial and temporal phenomena spanning from molecular to tissue scales.[13][14]

The laboratory' contributions are the direct connection of genes to segmentation rhythm, and the discovery that the rhythm also involves physical, collective processes at multi-cellular and tissue scales.[15][16]

Distinctions

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Oates is a member of the British Society of Developmental Biology.[17] He is the recipient of the R.K. Mortenson Prize for Biochemistry 1991.

Selected works

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References

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  1. ^ a b "Brexit: closer cooperation with the UK cannot replace participation in Horizon 2020 | ETH-Board". www.ethrat.ch. Archived from the original on 9 January 2021. Retrieved 21 December 2020.
  2. ^ a b "oateslab". www.epfl.ch. Retrieved 21 December 2020.
  3. ^ a b "Andrew Charles Oates". people.epfl.ch. Retrieved 21 December 2020.
  4. ^ a b "New deans for the Basic Sciences and Life Sciences". 12 November 2020. {{cite journal}}: Cite journal requires |journal= (help)
  5. ^ Nicholson, S. E.; Oates, A. C.; Harpur, A. G.; Ziemiecki, A.; Wilks, A. F.; Layton, J. E. (12 April 1994). "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation". Proceedings of the National Academy of Sciences. 91 (8): 2985–2988. Bibcode:1994PNAS...91.2985N. doi:10.1073/pnas.91.8.2985. ISSN 0027-8424. PMC 43499. PMID 7512720.
  6. ^ Oates, Andrew C; Bruce, Ashley E.E; Ho, Robert K (August 2000). "Too Much Interference: Injection of Double-Stranded RNA Has Nonspecific Effects in the Zebrafish Embryo". Developmental Biology. 224 (1): 20–28. doi:10.1006/dbio.2000.9761. PMID 10898958.
  7. ^ Schröter, Christian; Herrgen, Leah; Cardona, Albert; Brouhard, Gary J.; Feldman, Benjamin; Oates, Andrew C. (March 2008). "Dynamics of zebrafish somitogenesis". Developmental Dynamics. 237 (3): 545–553. doi:10.1002/dvdy.21458. PMID 18265021. S2CID 7038940.
  8. ^ Uriu, Koichiro; Ares, Saúl; Oates, Andrew C.; Morelli, Luis G. (21 March 2013). "Dynamics of mobile coupled phase oscillators". Physical Review E. 87 (3): 032911. Bibcode:2013PhRvE..87c2911U. doi:10.1103/PhysRevE.87.032911. hdl:11336/2452. ISSN 1539-3755.
  9. ^ Soroldoni, D.; Jorg, D. J.; Morelli, L. G.; Richmond, D. L.; Schindelin, J.; Julicher, F.; Oates, A. C. (11 July 2014). "A Doppler effect in embryonic pattern formation". Science. 345 (6193): 222–225. Bibcode:2014Sci...345..222S. doi:10.1126/science.1253089. ISSN 0036-8075. PMC 7611034. PMID 25013078. S2CID 206556621.
  10. ^ "King's College London - Randall Seminar: Professor Andrew Oates". www.kcl.ac.uk. Retrieved 21 December 2020.
  11. ^ Sanctuary, Hillary (25 August 2020). "Andrew Oates, a Passion for Cycles". {{cite journal}}: Cite journal requires |journal= (help)
  12. ^ Naganathan, Sundar R.; Oates, Andrew C. (October 2017). "Mechanochemical coupling and developmental pattern formation". Current Opinion in Systems Biology. 5: 104–111. doi:10.1016/j.coisb.2017.09.007.
  13. ^ "Research". www.epfl.ch. Retrieved 21 December 2020.
  14. ^ Lleras Forero, Laura; Narayanan, Rachna; Huitema, Leonie FA; VanBergen, Maaike; Apschner, Alexander; Peterson-Maduro, Josi; Logister, Ive; Valentin, Guillaume; Morelli, Luis G; Oates, Andrew C; Schulte-Merker, Stefan (6 April 2018). Whitfield, Tanya T. (ed.). "Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock". eLife. 7: e33843. doi:10.7554/eLife.33843. ISSN 2050-084X. PMC 5962341. PMID 29624170. S2CID 4605280.
  15. ^ Oates, Andrew C (August 2020). "Waiting on the Fringe: cell autonomy and signaling delays in segmentation clocks". Current Opinion in Genetics & Development. 63: 61–70. doi:10.1016/j.gde.2020.04.008. PMID 32505051.
  16. ^ Venzin, Olivier F.; Oates, Andrew C. (April 2020). "What are you synching about? Emerging complexity of Notch signaling in the segmentation clock". Developmental Biology. 460 (1): 40–54. doi:10.1016/j.ydbio.2019.06.024. PMID 31302101.
  17. ^ "Newsletter" (PDF). British Society for Developmental Biology.
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