BRK1

BRK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3P8C, 4N78
Identifiers
Aliases	BRK1, C3orf10, MDS027, hHBrk1, HSPC300, BRICK1, SCAR/WAVE actin nucleating complex subunit, BRICK1 subunit of SCAR/WAVE actin nucleating complex
External IDs	OMIM: 611183; MGI: 1915406; HomoloGene: 10210; GeneCards: BRK1; OMA:BRK1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	10,127,190 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	113,593,912 bp
RNA expression pattern
	Top expressed in
	sperm; ; skin of arm; ; islet of Langerhans; ; right testis; ; monocyte; ; tibial arteries; ; left coronary artery; ; right coronary artery; ; left testis; ; smooth muscle tissue;
	Top expressed in
	medullary collecting duct; ; external carotid artery; ; endocardial cushion; ; saccule; ; internal carotid artery; ; ureter; ; renal corpuscle; ; olfactory tubercle; ; epithelium of lens; ; otic vesicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein-containing complex binding; identical protein binding;
Cellular component	cytoplasm; cytosol; extracellular exosome; cytoskeleton; SCAR complex; lamellipodium;
Biological process	vascular endothelial growth factor receptor signaling pathway; Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; in utero embryonic development; positive regulation of lamellipodium assembly; actin cytoskeleton organization; Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of cell population proliferation; protein homotrimerization; actin filament organization; cell motility; regulation of actin polymerization or depolymerization; positive regulation of protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	55845
	101314
	ENSG00000254999
	ENSMUSG00000033940
	Q8WUW1
	Q91VR8
	NM_018462
	NM_133937
	NP_060932
	NP_598698
	Wikidata
View/Edit Human	View/Edit Mouse

BRICK1 is a putative micropeptide protein that in humans is encoded by the C3orf10 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000254999 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033940 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maranchie JK, Afonso A, Albert PS, Kalyandrug S, Phillips JL, Zhou S, Peterson J, Ghadimi BM, Hurley K, Riss J, Vasselli JR, Ried T, Zbar B, Choyke P, Walther MM, Klausner RD, Linehan WM (Jan 2004). "Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location". Human Mutation. 23 (1): 40–6. doi:10.1002/humu.10302. PMID 14695531. S2CID 20671312.
^ "Entrez Gene: C3orf10 chromosome 3 open reading frame 10".

External links

Human BRK1 genome location and BRK1 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein BRICK1

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000254999 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033940 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14695531-5] Maranchie JK, Afonso A, Albert PS, Kalyandrug S, Phillips JL, Zhou S, Peterson J, Ghadimi BM, Hurley K, Riss J, Vasselli JR, Ried T, Zbar B, Choyke P, Walther MM, Klausner RD, Linehan WM (Jan 2004). "Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location". Human Mutation. 23 (1): 40–6. doi:10.1002/humu.10302. PMID 14695531. S2CID 20671312.

[entrez-6] "Entrez Gene: C3orf10 chromosome 3 open reading frame 10".

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[5]

[6]

References

Further reading

External links