CSN3 (gene)

CSN3
Identifiers
Aliases	CSN3, CSN10, CSNK, KCA, CNS10, casein kappa
External IDs	OMIM: 601695; MGI: 107461; HomoloGene: 3818; GeneCards: CSN3; OMA:CSN3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	70,251,474 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	88,080,524 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; minor salivary glands; ; olfactory zone of nasal mucosa; ; tonsil; ; epithelium of lactiferous gland; ; gonad; ; lactiferous duct; ; lymph node; ; islet of Langerhans; ; uterine tube;
	Top expressed in
	lactiferous gland; ; molar; ; parotid gland; ; right ventricle; ; embryo; ; lacrimal gland; ; muscle of thigh; ; lip; ; olfactory epithelium; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	extracellular region; extracellular space;
Biological process	protein stabilization; lactation; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1448
	12994
	ENSG00000171209
	ENSMUSG00000001622
	P07498
	P06796
	NM_005212; NM_001394997
	NM_007786; NM_001356570; NM_001356571
	NP_005203
	NP_031812; NP_001343499; NP_001343500
	Wikidata
View/Edit Human	View/Edit Mouse

Kappa-casein is a protein that in humans is encoded by the CSN3 gene.^[5]^[6]^[7]

Interactions

CSN3 (gene) has been shown to interact with EIF3S6.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171209 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001622 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Edlund A, Johansson T, Leidvik B, Hansson L (Nov 1996). "Structure of the human kappa-casein gene". Gene. 174 (1): 65–9. doi:10.1016/0378-1119(96)00351-4. PMID 8863730.
^ Fujiwara Y, Miwa M, Nogami M, Okumura K, Nobori T, Suzuki T, Ueda M (Mar 1997). "Genomic organization and chromosomal localization of the human casein gene family". Hum Genet. 99 (3): 368–73. doi:10.1007/s004390050374. PMID 9050925. S2CID 8299892.
^ "Entrez Gene: CSN3 casein kappa".
^ Hoareau Alves, Karine; Bochard Valérie; Réty Stéphane; Jalinot Pierre (Sep 2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3). Netherlands: 15–21. doi:10.1016/S0014-5793(02)03147-2. ISSN 0014-5793. PMID 12220626. S2CID 39308598.

External links

Human CSN3 genome location and CSN3 gene details page in the UCSC Genome Browser.

Bergström S, Hansson L, Hernell O, et al. (1993). "Cloning and sequencing of human kappa-casein cDNA". DNA Seq. 3 (4): 245–6. doi:10.3109/10425179209034024. PMID 1296818.
Brignon G, Chtourou A, Ribadeau-Dumas B (1985). "Preparation and amino acid sequence of human kappa-casein". FEBS Lett. 188 (1): 48–54. doi:10.1016/0014-5793(85)80872-3. PMID 4018271. S2CID 83551753.
Fiat AM, Jollès J, Aubert JP, et al. (1981). "Localisation and importance of the sugar part of human casein". Eur. J. Biochem. 111 (2): 333–9. doi:10.1111/j.1432-1033.1980.tb04946.x. PMID 7460900.
Plowman JE, Creamer LK, Liddell MJ, Cross JJ (1999). "Structural features of a peptide corresponding to human kappa-casein residues 84-101 by 1H-nuclear magnetic resonance spectroscopy". J. Dairy Res. 66 (1): 53–63. doi:10.1017/S0022029998003318. PMID 10191473. S2CID 22589486.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Benítez MJ, Cochet C, Jiménez JS (2002). "A surface plasmon resonance study of the interactions between the component subunits of protein kinase CK2 and two protein substrates, casein and calmodulin". Mol. Cell. Biochem. 227 (1–2): 31–6. doi:10.1023/A:1013140220121. PMID 11827172. S2CID 19295218.
Sood SM, Slatter CW (2003). "Suspension of the calcium-sensitive human beta-caseins by human kappa-casein". J. Dairy Sci. 85 (6): 1353–6. doi:10.3168/jds.S0022-0302(02)74200-8. PMID 12146463.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kim YJ, Park S, Oh YK, et al. (2005). "Purification and characterization of human caseinomacropeptide produced by a recombinant Saccharomyces cerevisiae". Protein Expr. Purif. 41 (2): 441–6. doi:10.1016/j.pep.2005.02.021. PMID 15866733.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171209 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001622 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8863730-5] Edlund A, Johansson T, Leidvik B, Hansson L (Nov 1996). "Structure of the human kappa-casein gene". Gene. 174 (1): 65–9. doi:10.1016/0378-1119(96)00351-4. PMID 8863730.

[pmid9050925-6] Fujiwara Y, Miwa M, Nogami M, Okumura K, Nobori T, Suzuki T, Ueda M (Mar 1997). "Genomic organization and chromosomal localization of the human casein gene family". Hum Genet. 99 (3): 368–73. doi:10.1007/s004390050374. PMID 9050925. S2CID 8299892.

[entrez-7] "Entrez Gene: CSN3 casein kappa".

[pmid12220626-8] Hoareau Alves, Karine; Bochard Valérie; Réty Stéphane; Jalinot Pierre (Sep 2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3). Netherlands: 15–21. doi:10.1016/S0014-5793(02)03147-2. ISSN 0014-5793. PMID 12220626. S2CID 39308598.

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Interactions

References

External links

Further reading