Caprin-1

CAPRIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WBE, 4WBP
Identifiers
Aliases	CAPRIN1, GPIAP1, GPIP137, GRIP137, M11S1, RNG105, p137GPI, cell cycle associated protein 1
External IDs	OMIM: 601178; MGI: 1858234; HomoloGene: 4310; GeneCards: CAPRIN1; OMA:CAPRIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	34,102,610 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	103,627,994 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; Achilles tendon; ; islet of Langerhans; ; endometrium; ; left testis; ; epithelium of colon; ; right testis; ; stromal cell of endometrium; ; gonad;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ureter; ; primitive streak; ; maxillary prominence; ; abdominal wall; ; external carotid artery; ; internal carotid artery; ; mandibular prominence; ; medullary collecting duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	cytoplasmic stress granule; dendrite; P-body; integral component of plasma membrane; cell projection; membrane; cytoplasm; cytosol; synapse;
Biological process	cell differentiation; negative regulation of translation; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4076
	53872
	ENSG00000135387
	ENSMUSG00000027184
	Q14444
	Q60865
	NM_005898; NM_203364
	NM_001111289; NM_001111290; NM_001111291; NM_001111292; NM_016739
	NP_005889; NP_976240
	NP_001104759; NP_001104760; NP_001104761; NP_001104762; NP_058019
	Wikidata
View/Edit Human	View/Edit Mouse

Caprin-1 is a protein that in humans is encoded by the CAPRIN1 gene.^[5]^[6]^[7]^[8]^[9]^[10] It is suggested that Caprin1 (a.k.a. RNG105) is essential for the formation of long-term memory.^[11]

Clinical significance

In 2022, loss-of-function mutations of the CAPRIN1 gene were shown to result in an autosomal-dominant disorder. Patients having the newly-discovered disorder suffer from language impairment, speech delay, intellectual disability, ADHD and autism spectrum disorder.^[12] Somatically, they have respiratory problems, limb/skeletal anomalies, developmental delay, feeding difficulties, seizures and ophthalmologic problems.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135387 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027184 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ellis JA, Luzio JP (September 1995). "Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells". The Journal of Biological Chemistry. 270 (35): 20717–20723. doi:10.1074/jbc.270.35.20717. PMID 7657653.
^ Wang B, David MD, Schrader JW (October 2005). "Absence of caprin-1 results in defects in cellular proliferation". Journal of Immunology. 175 (7): 4274–4282. doi:10.4049/jimmunol.175.7.4274. PMID 16177067.
^ Solomon S, Xu Y, Wang B, David MD, Schubert P, Kennedy D, Schrader JW (March 2007). "Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs". Molecular and Cellular Biology. 27 (6): 2324–42. doi:10.1128/MCB.02300-06. PMC 1820512. PMID 17210633.
^ Grill B, Wilson GM, Zhang KX, Wang B, Doyonnas R, Quadroni M, Schrader JW (February 2004). "Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins". Journal of Immunology. 172 (4): 2389–2400. doi:10.4049/jimmunol.172.4.2389. PMID 14764709.
^ Katsafanas GC, Moss B (December 2004). "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer". The Journal of Biological Chemistry. 279 (50): 52210–52217. doi:10.1074/jbc.M411033200. PMID 15471883.
^ "Entrez Gene: GPIAP1 GPI-anchored membrane protein 1".
^ Nakayama K, Ohashi R, Shinoda Y, Yamazaki M, Abe M, Fujikawa A, et al. (November 2017). "RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation". eLife. 6. doi:10.7554/eLife.29677. PMC 5697933. PMID 29157358.
^ Pavinato L, Delle Vedove A, Carli D, Ferrero M, Carestiato S, Howe JL, Agolini E, Coviello DA, van de Laar I, Au PY, Di Gregorio E, Fabbiani A, Croci S, Mencarelli MA, Bruno LP, Renieri A, Veltra D, Sofocleous C, Faivre L, Mazel B, Safraou H, Denommé-Pichon AS, van Slegtenhorst MA, Giesbertz N, van Jaarsveld RH, Childers A, Rogers RC, Novelli A, De Rubeis S, Buxbaum JD, Scherer SW, Ferrero GB, Wirth B, Brusco A (July 2022). "CAPRIN1 haploinsufficiency causes a neurodevelopmental disorder with language impairment, ADHD and ASD". Brain: A Journal of Neurology. 146 (2): 534–548. doi:10.1093/brain/awac278. PMC 10169411. PMID 35979925.

Clinical significance

References

Further reading