David MacLennan

David MacLennan
David MacLennan
Born	July 3, 1937; Swan River, Manitoba, Canada
Died	June 24, 2020 (aged 82); Toronto, Ontario, Canada
Education	University of Manitoba (B.S.A.); Purdue University (M.S., Ph.D.);
	Scientific career
Fields	Biochemistry, Genetics
Institutions	University of Toronto
Thesis	Compartmentation of organic acids in plant tissues (1963)
Doctoral advisor	Harry Beevers

David Herman MacLennan OC OOnt FRS FRSC (July 3, 1937 - June 24, 2020) was a Canadian biochemist and geneticist known for his basic work on proteins that regulate calcium flux through the sarcoplasmic reticulum (SR), thereby regulating muscle contraction and relaxation, and for his discoveries in the field of muscle diseases caused by genetic defects in calcium regulatory proteins.^[1]

Born in Swan River, Manitoba, to Douglas MacLennan and Sigriður Sigurðardóttir, he received a BSA from the University of Manitoba in 1959 and a DSc (hc) in 2001.^[2] He received MS (1961) and PhD (1963) degrees from Purdue University under Harry Beevers, and was then a postdoctoral fellow (1963–1964) under David E. Green and an assistant professor (1964–1968) at the University of Wisconsin–Madison. In 1969, he was appointed associate professor in the Banting and Best Department of Medical Research^[3] and, later, professor (1974), chair (1978–1990), J. W. Billes Professor of Medical Research (1987–2007) and university professor (1993–2015).

MacLennan made fundamental contributions to our understanding of the mechanism of ion transport by SR calcium pumps, the storage of calcium in the SR by acidic lumenal proteins and the release of calcium from the SR by calcium release channels. He led teams that defined the genetic basis for the human skeletal muscle diseases, malignant hyperthermia, central core disease and Brody disease and was part of the team that demonstrated that mutations in phospholamban, a regulator of the calcium pump, can cause cardiomyopathy.^[4] His identification of a calcium release channel mutation that causes porcine stress syndrome resulted in a diagnostic test that has decreased the incidence of the disease dramatically, with substantial economic benefits to the swine industry.

Honours and awards

1974 Ayerst Award of the Canadian Biochemical Society
1985 Fellow of the Royal Society of Canada
1990 National Lecturer Award of the Biophysical Society
1991 Gairdner Foundation International Award
1994 Fellow of the Royal Society of London^[5]
1997 Killam Prize (Health Sciences) of the Canada Council for the Arts
2000 Royal Society Glaxo Wellcome Prize, Medal and Lecture
2001 Fellow of the International Society for Heart Research
2001 Foreign Associate of the National Academy of Sciences USA
2001 Honorary Doctor of Science, University of Manitoba
2001 Officer of the Order of Canada
2004 Honorary Member of the Japanese Biochemical Society
2009 Member of the Order of Ontario
2013 Member of the Canadian Medical Hall of Fame
2015 Foreign Honorary Member American Academy of Arts and Sciences

Notes

^ "MacLennan Lab Page". U of T. Archived from the original on 2013-07-14. Retrieved 2013-08-09.
^ "University of Manitoba Lab Page". U of M. Retrieved 2013-08-09.
^ "Terrence Donnelly Centre Lab Page". U of T BBDMR. Archived from the original on 2013-10-11. Retrieved 2013-08-09.
^ Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U; et al. (2003). "Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban". Science. 299 (5611): 1410–3. doi:10.1126/science.1081578. PMID 12610310. S2CID 12253445.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Reithmeier, Reinhart (2021). "David Herman MacLennan. 3 July 1937—24 June 2020". Biographical Memoirs of Fellows of the Royal Society. 71: 317–333. doi:10.1098/rsbm.2021.0005. S2CID 235598967.

External links

Home Page for David MacLennan’s Laboratory
ISI Highly Cited Researchers
University of Manitoba Distinguished Graduates
Canada Council for the Arts Archived 2012-02-07 at the Wayback Machine
Journal of Biological Chemistry Archived 2008-07-27 at the Wayback Machine

[1] "MacLennan Lab Page". U of T. Archived from the original on 2013-07-14. Retrieved 2013-08-09.

[2] "University of Manitoba Lab Page". U of M. Retrieved 2013-08-09.

[3] "Terrence Donnelly Centre Lab Page". U of T BBDMR. Archived from the original on 2013-10-11. Retrieved 2013-08-09.

[pmid12610310-4] Schmitt JP, Kamisago M, Asahi M, Li GH, Ahmad F, Mende U; et al. (2003). "Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban". Science. 299 (5611): 1410–3. doi:10.1126/science.1081578. PMID 12610310. S2CID 12253445.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[5] Reithmeier, Reinhart (2021). "David Herman MacLennan. 3 July 1937—24 June 2020". Biographical Memoirs of Fellows of the Royal Society. 71: 317–333. doi:10.1098/rsbm.2021.0005. S2CID 235598967.

[1]

[2]

[3]

[4]

[5]