Draft:Daniel Pine

Daniel S. Pine is an American physician, who is the chief, Section on Development and Affective Neuroscience at the National Institute of Mental Health (NIMH) Intramural Research Program.

After graduating from medical school at the University of Chicago, Pine spent 10 years in training and research on child psychiatry at the College of Physicians and Surgeons of Columbia University. Since medical school, he has been engaged continuously in research focusing on the epidemiology, biology, and treatment of pediatric mental illnesses. His areas of expertise include biological and pharmacological aspects of mood, anxiety, and behavioral disorders in children, as well as classification of psychopathology across the lifespan. This expertise is reflected in more than 300 peer-reviewed papers.

As of his time at the NIMH, his research group is examining the degree to which mood and anxiety disorders in children and adolescents are associated with underlying abnormalities in the amygdala, prefrontal cortex, and associated brain regions.

Pine has served as the Chair of the Psychopharmacologic Drug Advisory Committee for the Food and Drug Administration and Chair of the Child and Adolescent Diagnosis Group for the DSM-5 Task Force. He has received many awards, including the Joel Elkes Award from the American College of Neuropsychopharmacology, the Blanche Ittelson Award from the American Psychiatric Association, and the Ruane Prize from the Brain & Behavior Research Foundation.

Selected Publications

• Beesdo K, Lau JY, Guyer AE, McClure-Tone EB, Monk CS, Nelson EE, Fromm SJ, Goldwin MA, Wittchen HU, Leibenluft E, Ernst M, Pine DS (2009). Common and distinct amygdala-function perturbations in depressed vs anxious adolescents. Arch Gen Psychiatry 66, 275-85. https://doi.org/10.1001/archgenpsychiatry.2008.545.
• Alvarez RP, Biggs A, Chen G, Pine DS, Grillon C (2008). Contextual fear conditioning in humans: cortical-hippocampal and amygdala contributions. J Neurosci 28, 6211-9. https://doi.org/10.1523/JNEUROSCI.1246-08.2008.
• Blair K, Geraci M, Devido J, McCaffrey D, Chen G, Vythilingam M, Ng P, Hollon N, Jones M, Blair RJ, Pine DS (2008). Neural response to self- and other referential praise and criticism in generalized social phobia. Arch Gen Psychiatry 65, 1176-84. https://doi.org/10.1001/archpsyc.65.10.1176.
• Pine DS, Helfinstein SM, Bar-Haim Y, Nelson E, Fox NA (2009). Challenges in developing novel treatments for childhood disorders: lessons from research on anxiety. Neuropsychopharmacology 34, 213-28. https://doi.org/10.1038/npp.2008.113.
• Guyer AE, Lau JY, McClure-Tone EB, Parrish J, Shiffrin ND, Reynolds RC, Chen G, Blair RJ, Leibenluft E, Fox NA, Ernst M, Pine DS, Nelson EE (2008). Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety. Arch Gen Psychiatry 65, 1303-12. https://doi.org/10.1001/archpsyc.65.11.1303.