FCRL4

FCRL4
Identifiers
Aliases	FCRL4, CD307d, FCRH4, IGFP2, IRTA1, Fc receptor like 4
External IDs	OMIM: 605876; HomoloGene: 88926; GeneCards: FCRL4; OMA:FCRL4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	157,598,085 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; epithelium of nasopharynx; ; testicle; ; mucosa of ileum; ; appendix; ; lymph node; ; tibialis anterior muscle; ; tonsil; ; skin of thigh; ; deltoid muscle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; cell surface;
Biological process	adaptive immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	83417
	n/a
	ENSG00000163518
	n/a
	Q96PJ5
	n/a
	NM_031282
	n/a
	NP_112572
	n/a
	Wikidata
View/Edit Human

Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed on human memory B cells which resides in epithelial tissues.^[3]^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163518 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hatzivassiliou G, Miller I, Takizawa J, Palanisamy N, Rao PH, Iida S, Tagawa S, Taniwaki M, Russo J, Neri A, Cattoretti G, Clynes R, Mendelsohn C, Chaganti RS, Dalla-Favera R (Apr 2001). "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy". Immunity. 14 (3): 277–89. doi:10.1016/S1074-7613(01)00109-1. PMID 11290337.
^ Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
^ "Entrez Gene: FCRL4 Fc receptor-like 4".

Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841. S2CID 1971426.
Ehrhardt GR, Hsu JT, Gartland L, et al. (2005). "Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells". J. Exp. Med. 202 (6): 783–91. doi:10.1084/jem.20050879. PMC 2212938. PMID 16157685.
Jöhrens K, Shimizu Y, Anagnostopoulos I, et al. (2006). "T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution". Haematologica. 90 (8): 1070–7. PMID 16079106.
Falini B, Tiacci E, Pucciarini A, et al. (2004). "Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)". Blood. 102 (10): 3684–92. doi:10.1182/blood-2003-03-0750. PMID 12881317.
Guselnikov SV, Ershova SA, Mechetina LV, et al. (2002). "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1". Immunogenetics. 54 (2): 87–95. doi:10.1007/s00251-002-0436-x. PMID 12037601. S2CID 9452957.
Miller I, Hatzivassiliou G, Cattoretti G, et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662–9. doi:10.1182/blood.V99.8.2662. PMID 11929751.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163518 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11290337-3] Hatzivassiliou G, Miller I, Takizawa J, Palanisamy N, Rao PH, Iida S, Tagawa S, Taniwaki M, Russo J, Neri A, Cattoretti G, Clynes R, Mendelsohn C, Chaganti RS, Dalla-Favera R (Apr 2001). "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy". Immunity. 14 (3): 277–89. doi:10.1016/S1074-7613(01)00109-1. PMID 11290337.

[pmid11493702-4] Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.

[entrez-5] "Entrez Gene: FCRL4 Fc receptor-like 4".

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[3]

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References

Further reading