GSTT2

GSTT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MPF
Identifiers
Aliases	GSTT2, GSTT2B, glutathione S-transferase theta 2 (gene/pseudogene)
External IDs	OMIM: 600437; MGI: 106188; HomoloGene: 37358; GeneCards: GSTT2; OMA:GSTT2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	23,983,915 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,673,258 bp
RNA expression pattern
	Top expressed in
	testicle; ; stromal cell of endometrium; ; superior frontal gyrus; ; prefrontal cortex; ; fundus; ; right adrenal cortex; ; apex of heart; ; primary visual cortex; ; left adrenal gland; ; ascending aorta;
	Top expressed in
	right kidney; ; human kidney; ; proximal tubule; ; duodenum; ; left lobe of liver; ; spermatocyte; ; yolk sac; ; cervix; ; embryo; ; transitional epithelium of urinary bladder;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; glutathione transferase activity;
Cellular component	extracellular exosome; cytoplasm;
Biological process	glutathione metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2953
	14872
	ENSG00000099984; ENSG00000277897
	ENSMUSG00000033318
	P0CG29
	Q61133
	NM_000854; NM_001302670
	NM_010361
	NP_000845; NP_001289599
	NP_034491
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene.^[5]^[6]^[7]

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.^[7]

References

^ ^a ^b ^c ENSG00000277897 GRCh38: Ensembl release 89: ENSG00000099984, ENSG00000277897 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033318 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID 7789971.
^ Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 (3): 617–23. doi:10.1042/bj3340617. PMC 1219731. PMID 9729470.
^ ^a ^b "Entrez Gene: GSTT2 glutathione S-transferase theta 2".

Hussey AJ, Hayes JD (1992). "Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate". Biochem. J. 286 (3): 929–35. doi:10.1042/bj2860929. PMC 1132992. PMID 1417752.
Whittington AT, Webb GC, Baker RT, Board PG (1996). "Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1". Genomics. 33 (1): 105–11. doi:10.1006/geno.1996.0165. PMID 8617493.
Webb G, Vaska V, Coggan M, Board P (1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.
Mainwaring GW, Williams SM, Foster JR, et al. (1996). "The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human". Biochem. J. 318 (1): 297–303. doi:10.1042/bj3180297. PMC 1217621. PMID 8761485.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Chelvanayagam G, Wilce MC, Parker MW, et al. (1997). "Homology model for the human GSTT2 Theta class glutathione transferase". Proteins. 27 (1): 118–30. doi:10.1002/(SICI)1097-0134(199701)27:1<118::AID-PROT12>3.0.CO;2-Q. PMID 9037717. S2CID 35684018.
Rossjohn J, McKinstry WJ, Oakley AJ, et al. (1998). "Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site". Structure. 6 (3): 309–22. doi:10.1016/S0969-2126(98)00034-3. PMID 9551553.
de Bruin WC, Wagenmans MJ, Board PG, Peters WH (1999). "Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers". Carcinogenesis. 20 (8): 1453–7. doi:10.1093/carcin/20.8.1453. PMID 10426791.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
de Bruin WC, Wagenmans MJ, Peters WH (2000). "Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract". Jpn. J. Cancer Res. 91 (3): 310–6. doi:10.1111/j.1349-7006.2000.tb00946.x. PMC 5926361. PMID 10760690.
Sprenger R, Schlagenhaufer R, Kerb R, et al. (2001). "Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation". Pharmacogenetics. 10 (6): 557–65. doi:10.1097/00008571-200008000-00009. PMID 10975610.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
De Maria F, Pedersen JZ, Caccuri AM, et al. (2004). "The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide". J. Biol. Chem. 278 (43): 42283–93. doi:10.1074/jbc.M305568200. PMID 12871945.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Jang SG, Kim IJ, Kang HC, et al. (2007). "GSTT2 promoter polymorphisms and colorectal cancer risk". BMC Cancer. 7: 16. doi:10.1186/1471-2407-7-16. PMC 1793996. PMID 17250773.

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[refGRCh38Ensembl-1] ENSG00000277897 GRCh38: Ensembl release 89: ENSG00000099984, ENSG00000277897 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033318 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7789971-5] Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID 7789971.

[pmid9729470-6] Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 (3): 617–23. doi:10.1042/bj3340617. PMC 1219731. PMID 9729470.

[entrez-7] "Entrez Gene: GSTT2 glutathione S-transferase theta 2".

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References

Further reading