Goblet cell carcinoid

Goblet cell carcinoid
Goblet cell carcinoid
Other names	Crypt cell carcinoma, neuroendocrine tumour with goblet cell differentiation
	Micrograph showing a goblet cell carcinoid. H&E stain.

The goblet cell carcinoid (GCC) is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells.^[1]

Sign and symptoms

GCCs may present as appendicitis.

Diagnosis

GCCs are diagnosed by pathology. They have a characteristic biphasic appearance which includes (1) goblet cell-like cells, and (2) neuroendocrine-type nuclear chromatin (stippled chromatin).

Prognosis

GCCs have an aggressive course compared to other appendiceal neuroendocrine tumours.^[1]

Treatment

GCCs are treated with surgery.

References

^ ^a ^b van Eeden S, Offerhaus GJ, Hart AA, et al. (December 2007). "Goblet cell carcinoid of the appendix: a specific type of carcinoma". Histopathology. 51 (6): 763–73. doi:10.1111/j.1365-2559.2007.02883.x. PMID 18042066.

External links

[pmid18042066-1] van Eeden S, Offerhaus GJ, Hart AA, et al. (December 2007). "Goblet cell carcinoid of the appendix: a specific type of carcinoma". Histopathology. 51 (6): 763–73. doi:10.1111/j.1365-2559.2007.02883.x. PMID 18042066.

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