KRT36

KRT36
Identifiers
Aliases	KRT36, HA6, KRTHA6, hHa6, keratin 36
External IDs	OMIM: 604540; MGI: 109364; HomoloGene: 88459; GeneCards: KRT36; OMA:KRT36 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,492,546 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,996,452 bp
RNA expression pattern
	Top expressed in
	testicle; ; body of tongue; ; superior surface of tongue; ; mucosa of esophagus; ; spleen; ; cervix; ; lymph node; ; skin of limb; ; skin of leg; ; granulocyte;
	Top expressed in
	lip; ; hair follicle; ; embryo; ; skin of external ear; ; skin of back; ; tongue; ; filiform papilla; ; skin of abdomen; ; mammary gland; ; oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; structural constituent of skin epidermis;
Cellular component	intermediate filament cytoskeleton; extracellular exosome; intermediate filament; cytosol;
Biological process	regulation of keratinocyte differentiation; keratinization; cornification; biological process;
	Sources:Amigo / QuickGO
Orthologs
	8689
	16673
	ENSG00000126337
	ENSMUSG00000020916
	O76013
	B1AQ75
	NM_003771
	NM_001174099; NM_008472
	NP_003762
	NP_001167570
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126337 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020916 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT36 keratin 36".

Fuchs E, Weber K (1994). "Intermediate filaments: structure, dynamics, function, and disease". Annu. Rev. Biochem. 63: 345–82. doi:10.1146/annurev.bi.63.070194.002021. PMID 7979242.
Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.

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