MED18

MED18
Identifiers
Aliases	MED18, p28b, mediator complex subunit 18, SRB5
External IDs	OMIM: 612384; MGI: 1914469; HomoloGene: 9756; GeneCards: MED18; OMA:MED18 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	28,335,965 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,191,232 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; islet of Langerhans; ; stromal cell of endometrium; ; lymph node; ; blood; ; rectum; ; granulocyte; ; skeletal muscle tissue; ; duodenum; ; appendix;
	Top expressed in
	Region I of hippocampus proper; ; hand; ; maxillary prominence; ; mandibular prominence; ; globus pallidus; ; intercostal muscle; ; internal carotid artery; ; parotid gland; ; external carotid artery; ; mesenteric lymph nodes;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coregulator activity; protein binding; ubiquitin protein ligase activity;
Cellular component	core mediator complex; mediator complex; nucleus; ubiquitin ligase complex;
Biological process	regulation of transcription by RNA polymerase II; termination of RNA polymerase II transcription; regulation of transcription, DNA-templated; transcription, DNA-templated; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	54797
	67219
	ENSG00000130772; ENSG00000284944
	ENSMUSG00000066042
	Q9BUE0
	Q9CZ82
	NM_001127350; NM_017638
	NM_026039
	NP_001120822; NP_060108
	NP_080315
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.^[5]

Function

Med18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.^[6]

^ ^a ^b ^c ENSG00000284944 GRCh38: Ensembl release 89: ENSG00000130772, ENSG00000284944 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066042 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Mediator complex subunit 18".
^ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17). American Society for Biochemistry & Molecular Biology (ASBMB): 15123–7. doi:10.1074/jbc.c300054200. PMID 12584197.

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