Margaret Faul
Margaret M. Faul | |
|---|---|
| Alma mater | University College Dublin Harvard University |
| Known for | Green chemistry, process science |
| Scientific career | |
| Thesis | (1992) |
| Doctoral advisor | David A. Evans |
Margaret M. Faul is an Irish American chemist and executive who has won multiple awards for innovations in process chemistry.
Background
[edit]Faul received her undergraduate degrees from University College, Dublin before embarking on doctoral studies with Professor David A. Evans at Harvard. Her studies focused mostly on metal-catalyzed nitrene transfer reactions[1] to produce aziridines, strained nitrogen precursors valued as pharmaceutical intermediates. Faul introduced multiple new wrinkles into this chemistry, including using chiral copper(I) catalysts[2] to produce enantiomerically-enriched aziridines, and using a variety of different nitrene sources for the transfer.
Research
[edit]Faul joined the process chemistry group at Eli Lilly in 1993, and joined Amgen's process group in 2003, rising eventually to its Executive Director. According to a biosketch at Organic Syntheses, Faul has expertise in Good Manufacturing Process scale-up of both chemical and biological therapeutics, and coordinates groups of external partners through licensing, regulatory, and program development issues.[3] She attributes much of Amgen's success in this area to early adoption of new technologies, such as supercritical carbon dioxide purification and ultra-high performance liquid chromatography (uPLC).[4]
Volunteer work
[edit]Faul is an Editorial Board member at Thieme journal Science of Synthesis.[5] She has served as the chair of the Enabling Technologies Consortium.[6][7]
Awards and honors
[edit]- 2019 - Fellow of the American Chemical Society (ACS)[8]
- 2019 - Inaugural Margaret M. Faul Women in Chemistry Award, Thieme Publishers[9]
- 2018 - Earl B. Barnes award for Chemical Research Management, ACS[10]
- 2017 - Accepted the Presidential Green Chemistry Challenge award on behalf of Amgen Process[11]
- 1986 - Hugh Ryan Memorial Medal, UCD
References
[edit]- ^ Evans, David A.; Bilodeau, Mark T.; Faul, Margaret M. (April 1994). "Development of the Copper-Catalyzed Olefin Aziridination Reaction". Journal of the American Chemical Society. 116 (7): 2742–2753. doi:10.1021/ja00086a007. ISSN 0002-7863.
- ^ Evans, David A.; Faul, Margaret M.; Bilodeau, Mark T.; Anderson, Benjamin A.; Barnes, David M. (June 1993). "Bis(oxazoline)-copper complexes as chiral catalysts for the enantioselective aziridination of olefins". Journal of the American Chemical Society. 115 (12): 5328–5329. doi:10.1021/ja00065a068. ISSN 0002-7863.
- ^ Faul, Margaret (2017). "Faul biosketch" (PDF). Organic Syntheses. Archived from the original (PDF) on 21 July 2017. Retrieved 19 November 2018.
- ^ Patel, Prachi (10 February 2017). "A Conversation with Margaret Faul". ACS Central Science. 3 (2): 141–142. doi:10.1021/acscentsci.7b00050. ISSN 2374-7943. PMC 5324089. PMID 28280781.
- ^ "Science of Synthesis Editorial Board - Thieme Chemistry - Georg Thieme Verlag". Thieme. Retrieved 19 November 2018.
- ^ "Portrait of Dr. Margaret Faul - Thieme Chemistry - Georg Thieme Verlag KG". Thieme. Retrieved 19 November 2018.
- ^ "Working Groups". ETC. Archived from the original on 19 November 2018. Retrieved 19 November 2018.
- ^ "2019 ACS Fellows". American Chemical Society. Retrieved 12 August 2019.
- ^ "Women in Chemistry Award - Thieme Chemistry - Georg Thieme Verlag KG". Thieme. Retrieved 19 November 2018.
- ^ "Earle B. Barnes Award for Leadership in Chemical Research Management: Margaret M. Faul | January 8, 2018 Issue - Vol. 96 Issue 2 | Chemical & Engineering News". cen.acs.org. Retrieved 19 November 2018.
- ^ "Amgen Wins the 2017 Green Chemistry Challenge Award". www.amgen.com. Retrieved 19 November 2018.