Morniflumate

Morniflumate
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M01AX22 (WHO) ;
Identifiers
	IUPAC name 2-morpholin-4-ylethyl 2-{[3-(trifluoromethyl)phenyl]amino}nicotinate;
CAS Number	65847-85-0 ;
PubChem CID	72106;
ChemSpider	65089 ;
UNII	R133MWH7X1;
KEGG	D05078 ;
CompTox Dashboard (EPA)	DTXSID6057798 ;
ECHA InfoCard	100.207.566
Chemical and physical data
Formula	C19H20F3N3O3
Molar mass	395.382 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c1cc(ccc1)Nc2ncccc2C(=O)OCCN3CCOCC3;
	InChI InChI=1S/C19H20F3N3O3/c20-19(21,22)14-3-1-4-15(13-14)24-17-16(5-2-6-23-17)18(26)28-12-9-25-7-10-27-11-8-25/h1-6,13H,7-12H2,(H,23,24) ; Key:LDXSPUSKBDTEKA-UHFFFAOYSA-N ;
	(verify)

Morniflumate is a nonsteroidal anti-inflammatory drug (NSAID).^[1]^[2]^[3]

References

^ Melica A, Donateo L, Gerardi R, Parenti M (1991). "[A new anti-inflammatory-analgesic-antipyretic, morniflumate, in the treatment of chronic recurring bronchitis]". Rivista Europea per le Scienze Mediche e Farmacologiche = European Review for Medical and Pharmacological Sciences = Revue Européenne Pour les Sciences Médicales et Pharmacologiques. 13 (1–2): 51–60. PMID 1796197.
^ Civelli M, Vigano T, Acerbi D, Caruso P, Giossi M, Bongrani S, Folco GC (July 1991). "Modulation of arachidonic acid metabolism by orally administered morniflumate in man". Agents and Actions. 33 (3–4): 233–9. doi:10.1007/bf01986568. PMID 1659152.
^ Schiantarelli P, Cadel S, Acerbi D (February 1984). "A gastroprotective anti-inflammatory agent: the beta-morpholinoethyl ester of niflumic acid (morniflumate)". Agents and Actions. 14 (2): 247–56. doi:10.1007/BF01966649. PMID 6608862.

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[1] Melica A, Donateo L, Gerardi R, Parenti M (1991). "[A new anti-inflammatory-analgesic-antipyretic, morniflumate, in the treatment of chronic recurring bronchitis]". Rivista Europea per le Scienze Mediche e Farmacologiche = European Review for Medical and Pharmacological Sciences = Revue Européenne Pour les Sciences Médicales et Pharmacologiques. 13 (1–2): 51–60. PMID 1796197.

[2] Civelli M, Vigano T, Acerbi D, Caruso P, Giossi M, Bongrani S, Folco GC (July 1991). "Modulation of arachidonic acid metabolism by orally administered morniflumate in man". Agents and Actions. 33 (3–4): 233–9. doi:10.1007/bf01986568. PMID 1659152.

[3] Schiantarelli P, Cadel S, Acerbi D (February 1984). "A gastroprotective anti-inflammatory agent: the beta-morpholinoethyl ester of niflumic acid (morniflumate)". Agents and Actions. 14 (2): 247–56. doi:10.1007/BF01966649. PMID 6608862.

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[2]

[3]

v t e Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones / pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bufexamac Bumadizone Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Mofezolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Pivoxicam Tenoxicam
propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pelubiprofen Piketoprofen Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
n-arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Floctafenine Flufenamic acid Flunixin Flutiazin Glafenine^† Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid
COX-2 inhibitors (coxibs)	Apricoxib Celecoxib (+tramadol) Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase / orgotein Tenidap
NSAID combinations	Ibuprofen/famotidine Ibuprofen/hydrocodone Ibuprofen/oxycodone Ibuprofen/paracetamol Meloxicam/bupivacaine Naproxen/diphenhydramine Naproxen/esomeprazole
Key: underline indicates initially developed first-in-class compound of specific group; ^#WHO-Essential Medicines; ^†withdrawn drugs; ^‡veterinary use.
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