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Nicole King

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Nicole King
Born1970
NationalityAmerican
Alma materIndiana University Bloomington;
Harvard University
Known forchoanoflagellates
AwardsMacArthur Fellowship
Scientific career
FieldsBiology
InstitutionsUniversity of California, Berkeley
Doctoral advisorRichard Losick

Nicole King (born 1970) is an American biologist and faculty member at the University of California, Berkeley in molecular and cell biology and integrative biology.[1] She was awarded a MacArthur Fellowship in 2005.[2] She has been an investigator with the Howard Hughes Medical Institute (HHMI) since 2013.

King studies the evolution of multicellularity and choanoflagellates. The goal of her work is to reconstruct how multicellular animals evolved from single-cell organisms.

Professional contributions

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King identified choanoflagellates as key organisms to answer questions about the origin of multicellularity. Prior to her work, it was unclear whether choanoflagellates or fungi were the closest outgroup to multicellular animals (also called "metazoans"). King's comparative genomics work in collaboration with Sean Carroll helped to elucidate the evolutionary "tree of life." In addition, work by King and colleagues showed that choanoflagellates possess several protein-coding genes that are highly related to protein-coding genes in animals at the base of the metazoan tree, such as sponges, cnidarians, and ctenophores.

More recent work by King demonstrates that molecules thought to underpin the transition to multicellarity also exist in choanoflagellates and therefore were present in the single-celled and colonial ancestors of animals. For example, one of the most abundant and important cell adhesion molecules in the animal kingdom, cadherin, exists in choanoflagellates. In animals, cadherins are required to keep cells attached to their neighbors, so it was a surprising to discover that cadherins predate the evolution of animals. In addition, King found that choanoflagellates possess genes that animal cells use to "talk" or signal to one another, such as Receptor tyrosine kinase.

King continues her studies on choanoflagellates and multicellularity as an associate professor at the University of California, Berkeley. King received her B.S. from Indiana University Bloomington in 1992, in the lab of Thom Kaufman, working on the genetic workhorse, the fruitfly, also known as Drosophila melanogaster. She did her graduate work at Harvard University (A.M., 1996, and PhD, 1999), studying the spore formation in Bacillus subtilis. After completing a postdoctoral fellowship at the University of Wisconsin–Madison in 2003, she accepted the position of assistant professor of genetics and development at the University of California, Berkeley.

King's lab has developed and maintained ChoanoBase, a genetic library about choanaflagellates.

Awards and recognitions

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Nicole King received the MacArthur Foundation's "genius" award (2005).

She received the Pew Scholars Program in the Biomedical Sciences (2004).

King also received an honorary Doctor of Science degree from Lehigh University on 18 May 2015, at the commencement ceremony.[3]

In 2022 King was elected to the National Academy of Sciences.[4]

References

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Notes

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  1. ^ "Faculty Research Page". berkeley.edu.
  2. ^ "MacArthur Profile". macfound.org. Archived from the original on 13 November 2006. Retrieved 24 October 2006.
  3. ^ "Honorary degree recipients named". lehigh.edu. 23 March 2015.
  4. ^ "2022 NAS Election". www.nasonline.org. Retrieved 15 May 2022.
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