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Protein-coding gene in the species Homo sapiens
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an enzyme that in humans is encoded by the PAPSS1 gene .[ 5] [ 6] [ 7]
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS ) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics . In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM][ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000138801 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028032 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Girard JP, Baekkevold ES, Amalric F (May 1998). "Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase" . FASEB J . 12 (7): 603–12. doi :10.1096/fasebj.12.7.603 PMID 9576487 . S2CID 19530341 . ^ ul Haque MF, King LM, Krakow D, Cantor RM, Rusiniak ME, Swank RT, Superti-Furga A, Haque S, Abbas H, Ahmad W, Ahmad M, Cohn DH (Oct 1998). "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse". Nat Genet . 20 (2): 157–62. doi :10.1038/2458 . PMID 9771708 . S2CID 13108930 . ^ a b "Entrez Gene: PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1" .
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PDB gallery
1x6v : The crystal structure of human 3'-phosphoadenosine-5'-phosphosulfate synthetase 1
1xjq : ADP Complex OF HUMAN PAPS SYNTHETASE 1
1xnj : APS complex of human PAPS synthetase 1
2ofw : Crystal structure of the APSK domain of human PAPSS1 complexed with 2 APS molecules
2ofx : crystal structure of the APSK domain of human PAPSS1 in complex with ADPMg and PAPS
2pey : Crystal structure of deletion mutant of APS-kinase domain of human PAPS-synthetase 1
2pez : Crystal structure of deletion mutant of APS-kinase domain of human PAPS-synthetase 1 in complex with cyclic PAPS and dADP
