PPP2R3B

PPP2R3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4I5L, 4I5N, 4MEW
Identifiers
Aliases	PPP2R3B, NYREN8, PPP2R3L, PPP2R3LY, PR48, protein phosphatase 2 regulatory subunit B''beta, PR70
External IDs	OMIM: 300339; MGI: 1335093; HomoloGene: 61474; GeneCards: PPP2R3B; OMA:PPP2R3B - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	386,955 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; left ventricle; ; right auricle; ; gastrocnemius muscle; ; sural nerve; ; skeletal muscle tissue; ; right uterine tube; ; right testis; ; left testis;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; protein binding; metal ion binding; protein phosphatase regulator activity;
Cellular component	protein phosphatase type 2A complex; nucleus; nucleoplasm;
Biological process	protein dephosphorylation; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	28227
	19054
	ENSG00000276438; ENSG00000273850; ENSG00000167393
	ENSMUSG00000093803
	Q9Y5P8
	Q9Z176
	NM_013239; NM_199326
	NM_001039134; NM_001163415; NM_011154
	NP_037371
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta is an enzyme that in humans is encoded by the PPP2R3B gene.^[4]^[5]

Function

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.^[5]

Interactions

PPP2R3B has been shown to interact with PPP2R1B,^[6] PPP2R1A,^[6]^[7] CDC6^[8] and PPP2CA.^[7]^[8]

References

^ ^a ^b ^c ENSG00000273850, ENSG00000167393 GRCh38: Ensembl release 89: ENSG00000276438, ENSG00000273850, ENSG00000167393 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schiebel K, Meder J, Rump A, Rosenthal A, Winkelmann M, Fischer C, Bonk T, Humeny A, Rappold G (February 2001). "Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region". Cytogenetics and Cell Genetics. 91 (1–4): 224–30. doi:10.1159/000056849. PMID 11173861. S2CID 536348.
^ ^a ^b "Entrez Gene: PPP2R3B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta".
^ ^a ^b Zhou J, Pham HT, Ruediger R, Walter G (Jan 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal. 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. PMC 1223084. PMID 12370081.
^ ^a ^b Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
^ ^a ^b Yan Z, Fedorov SA, Mumby MC, Williams RS (Feb 2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Molecular and Cellular Biology. 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. PMC 85219. PMID 10629059.

Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Ruediger R, Fields K, Walter G (Jan 1999). "Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens". Journal of Virology. 73 (1): 839–42. doi:10.1128/JVI.73.1.839-842.1999. PMC 103900. PMID 9847399.
Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
Yan Z, Fedorov SA, Mumby MC, Williams RS (Feb 2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Molecular and Cellular Biology. 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. PMC 85219. PMID 10629059.
Yokoyama N, Miller WT (Sep 2001). "Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS)". Oncogene. 20 (42): 6057–65. doi:10.1038/sj.onc.1204735. PMID 11593413. S2CID 23523206.
Stevens I, Janssens V, Martens E, Dilworth S, Goris J, Van Hoof C (Jan 2003). "Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues". European Journal of Biochemistry. 270 (2): 376–87. doi:10.1046/j.1432-1033.2003.03398.x. PMID 12605688.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gao Y, Kitagawa K, Hiramatsu Y, Kikuchi H, Isobe T, Shimada M, Uchida C, Hattori T, Oda T, Nakayama K, Nakayama KI, Tanaka T, Konno H, Kitagawa M (Dec 2006). "Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis". Cancer Research. 66 (24): 11623–31. doi:10.1158/0008-5472.CAN-06-2629. PMID 17178856.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000273850, ENSG00000167393 GRCh38: Ensembl release 89: ENSG00000276438, ENSG00000273850, ENSG00000167393 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11173861-4] Schiebel K, Meder J, Rump A, Rosenthal A, Winkelmann M, Fischer C, Bonk T, Humeny A, Rappold G (February 2001). "Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region". Cytogenetics and Cell Genetics. 91 (1–4): 224–30. doi:10.1159/000056849. PMID 11173861. S2CID 536348.

[entrez-5] "Entrez Gene: PPP2R3B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta".

[pmid12370081-6] Zhou J, Pham HT, Ruediger R, Walter G (Jan 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal. 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. PMC 1223084. PMID 12370081.

[pmid18782753-7] Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

[pmid10629059-8] Yan Z, Fedorov SA, Mumby MC, Williams RS (Feb 2000). "PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells". Molecular and Cellular Biology. 20 (3): 1021–9. doi:10.1128/MCB.20.3.1021-1029.2000. PMC 85219. PMID 10629059.

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Function

Interactions

References

Further reading