Ribosomal protein L13 leader
| L13_leader | |
|---|---|
 Consensus secondary structure and sequence conservation of Ribosomal protein L13 leader | |
| Identifiers | |
| Symbol | L13_leader |
| Rfam | RF00555 |
| Other data | |
| RNA type | Cis-reg; leader |
| GO | GO:0010468 |
| SO | SO:0000233 |
| PDB structures | PDBe |
| L13-Bacteroidia | |
|---|---|
 Consensus secondary structure and sequence conservation of L13-Bacteroidia ribosomal protein leader | |
| Identifiers | |
| Symbol | L13-Bacteroidia |
| Rfam | RF03127 |
| Other data | |
| RNA type | Cis-reg; leader |
| SO | SO:0000837 |
| PDB structures | PDBe |
L13 ribosomal protein leaders play a role in ribosome biogenesis as part of an autoregulatory mechanism to control the concentration of ribosomal proteins L13. Three structural classes of L13 ribosomal protein leaders were detected by different bioinformatics approaches: in B. subtilis and other low-GC Gram-positive bacteria.,[1] in E. coli [2][3] and in Bacteroidia.[4] Although these RNAs are expected to perform the same biological function, they do not appear to be structurally related to one another. The E. coli example has been experimentally confirmed, though the experiments are not comprehensive.[3][2] The other two leader structures are thus far not based on experimental support.
See also
[edit]References
[edit]- ^ Yao Z, Barrick J, Weinberg Z, Neph S, Breaker R, Tompa M, Ruzzo WL (July 2007). "A computational pipeline for high- throughput discovery of cis-regulatory noncoding RNA in prokaryotes". PLOS Comput Biol. 3 (7): e126. Bibcode:2007PLSCB...3..126Y. doi:10.1371/journal.pcbi.0030126. PMC 1913097. PMID 17616982.
- ^ a b Mustoe AM, Busan S, Rice GM, Hajdin CE, Peterson BK, Ruda VM, Kubica N, Nutiu R, Baryza JL, Weeks KM (March 2018). "Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing". Cell. 173 (1): 181–195.e18. doi:10.1016/j.cell.2018.02.034. PMC 5866243. PMID 29551268.
- ^ a b Meyer MM (March 2018). "rRNA Mimicry in RNA Regulation of Gene Expression". Microbiol Spectr. 6 (2). doi:10.1128/microbiolspec.RWR-0006-2017. PMID 29546840.
- ^ Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130): 130. doi:10.1186/s12866-020-01823-6. PMC 7247131. PMID 32448158.
External links
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