SMTN

SMTN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D87
Identifiers
Aliases	SMTN, smoothelin
External IDs	OMIM: 602127; MGI: 1354727; HomoloGene: 8482; GeneCards: SMTN; OMA:SMTN - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	31,104,757 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,490,612 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; popliteal artery; ; tibial arteries; ; muscle layer of sigmoid colon; ; body of uterus; ; apex of heart; ; left uterine tube; ; Descending thoracic aorta; ; ascending aorta; ; right coronary artery;
	Top expressed in
	tunica media of zone of aorta; ; ascending aorta; ; uterus; ; lip; ; aortic valve; ; temporal muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; structural constituent of muscle;
Cellular component	cytoplasm; cytoskeleton; actin cytoskeleton; microtubule organizing center; filamentous actin; nucleoplasm;
Biological process	smooth muscle contraction; muscle organ development; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	6525
	29856
	ENSG00000183963
	ENSMUSG00000020439
	P53814
	Q921U8
	NM_001207017; NM_001207018; NM_006932; NM_134269; NM_134270
	NM_001159284; NM_001284427; NM_001284428; NM_001284429; NM_013870
NP_001193946; NP_001193947; NP_008863; NP_599031; NP_599032;
	NP_001369567; NP_001369568; NP_001369569; NP_001369570; NP_001369571; NP_001369572; NP_001369573; NP_001369574; NP_001369575; NP_001369576; NP_001369577
	NP_001152756; NP_001271356; NP_001271357; NP_001271358; NP_038898
	Wikidata
View/Edit Human	View/Edit Mouse

Smoothelin is a protein that in humans is encoded by the SMTN gene.^[5]^[6]^[7]

This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183963 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020439 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Engelen JJ, Esterling LE, Albrechts JC, Detera-Wadleigh SD, van Eys GJ (Sep 1997). "Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 43 (2): 245–7. doi:10.1006/geno.1997.9999. PMID 9244445.
^ van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ (Sep 1996). "Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells". J Cell Biol. 134 (2): 401–11. doi:10.1083/jcb.134.2.401. PMC 2120883. PMID 8707825.
^ ^a ^b "Entrez Gene: SMTN smoothelin".

Luft FC (1999). "Differentiating one smooth operator from another". J. Mol. Med. 77 (2): 255–7. doi:10.1007/s001090050347. PMID 10023778. S2CID 20566620.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
van Eys GJ, Völler MC, Timmer ED, et al. (1997). "Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant". Cell Struct. Funct. 22 (1): 65–72. doi:10.1247/csf.22.65. hdl:2066/28540. PMID 9113392.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Krämer J, Aguirre-Arteta AM, Thiel C, et al. (1999). "A novel isoform of the smooth muscle cell differentiation marker smoothelin". J. Mol. Med. 77 (2): 294–8. doi:10.1007/s001090050352. PMID 10023782. S2CID 3017418.
Johansson B, Eriksson A, Ramaekers F, Thornell L (2000). "Smoothelin in adult and developing human arteries and myocardium". Histochem. Cell Biol. 112 (4): 291–9. doi:10.1007/s004180050450. PMID 10550614. S2CID 10117431.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Gsell S, Eschenhagen T, Kaspareit G, et al. (2000). "Apparent up-regulation of stimulatory G-protein alpha subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression". FASEB J. 14 (1): 17–26. doi:10.1096/fasebj.14.1.17. PMID 10627276. S2CID 15796476.
Krämer J, Quensel C, Meding J, et al. (2001). "Identification and characterization of novel smoothelin isoforms in vascular smooth muscle". J. Vasc. Res. 38 (2): 120–32. doi:10.1159/000051039. PMID 11316948. S2CID 1988528.
Rensen SS, Thijssen VL, De Vries CJ, et al. (2002). "Expression of the smoothelin gene is mediated by alternative promoters". Cardiovasc. Res. 55 (4): 850–63. doi:10.1016/S0008-6363(02)00491-1. PMID 12176134.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183963 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020439 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9244445-5] Engelen JJ, Esterling LE, Albrechts JC, Detera-Wadleigh SD, van Eys GJ (Sep 1997). "Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 43 (2): 245–7. doi:10.1006/geno.1997.9999. PMID 9244445.

[pmid8707825-6] van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ (Sep 1996). "Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells". J Cell Biol. 134 (2): 401–11. doi:10.1083/jcb.134.2.401. PMC 2120883. PMID 8707825.

[entrez-7] "Entrez Gene: SMTN smoothelin".

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References

Further reading