Talk:Gene targeting

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Major edit

Hi there, I'm planning on improving and expanding this article, but this will probably require a complete rewrite. I'm going to integrate all the information already included. Also I'm planning on removing the Nobel prize section, rather mentioning this elsewhere, I hope no one objects. BioStu (talk) 14:47, 8 August 2010 (UTC)[reply]

Assessment comment

The comment(s) below were originally left at Talk:Gene targeting/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

* Rated top as topic of the 2007 Nobel Prize in Medicine. - tameeria (talk) 05:25, 10 December 2007 (UTC)[reply]

Borderline stub/start article. Given the value of the subject, I'm rating as using stricter evaluation criteria and re-rating this as a "stub" – Clockwork Soul 14:59, 7 March 2008 (UTC)[reply]

Last edited at 14:59, 7 March 2008 (UTC). Substituted at 15:54, 29 April 2016 (UTC)

Wiki Education assignment: Research Process and Methodology - SU22 - Sect 202 - Tue

This article was the subject of a Wiki Education Foundation-supported course assignment, between 4 July 2022 and 16 August 2022. Further details are available on the course page. Student editor(s): Dc4825 (article contribs).

— Assignment last updated by Cindyhong123 (talk) 12:50, 9 August 2022 (UTC)[reply]

Proposed edits

I am a Post Graduate researcher at the University of Leeds working in the area of Gene Targeting. I've identified some areas for improvement with the lead for this article; 1. "The method can be used to delete a gene, remove exons" --> I am not aware of Gene targeting being used to remove DNA and can't see how this is possible through Homology directed repair(?). If no one has any objections I'd like to remove this. 2. "Gene targeting can be permanent or conditional" - I am not clear what this means. What does 'conditional' mean in this context? 3. "Conditions can be a specific time during development / life of the organism or limitation to a specific tissue, for example" - again it's not clear what this means. Is this referring to inducible GT? 4. "Gene targeting requires the creation of a specific vector for each gene of interest. However, it can be used for any gene, regardless of transcriptional activity or gene size" - this means very little out of context. I propose moving this point later in the article where it can be fully explained.

In general the lead is supposed to be understandable by a general audience, however the current lead is very technical and therefore not accessible. As such I would like to write a new lead that is more accessible. Yorkrosa (talk) 11:41, 19 May 2023 (UTC)[reply]

Thanks for setting out these issues, @Yorkrosa:. To me as a lay person, the current lead does have a problem of readability (which applies to a lot of Wikipedia articles on technical subjects). There are wikilinks for some technical terms, but that doesn't excuse the article from having to be written in a way that someone new to the topic isn't put off by the first few sentences. To learn that there are also some issues with the accuracy, and there are statements which don't make sense for an expert, suggests that the lead would benefit from a substantial rewrite. I encourage you to be bold in making changes and look forward to what improvements you'll make. MartinPoulter (talk) 13:46, 19 May 2023 (UTC)[reply]

Great, thanks very much @MartinPoulter! 194.80.232.19 (talk) 13:59, 19 May 2023 (UTC)[reply]