Template:Amphetamine base in marketed amphetamine medications

Amphetamine base in marketed amphetamine medications
drug		formula	molar mass ^{[note 1]}		amphetamine base ^{[note 2]}			amphetamine base in equal doses		doses with equal base content ^{[note 3]}
			(g/mol)		(percent)			(30 mg dose)
			total	base	total	dextro-	levo-	dextro-	levo-
dextroamphetamine sulfate^[2]^[3]		(C₉H₁₃N)₂•H₂SO₄	368.49	270.41	73.38%	73.38%	—	22.0 mg	—	30.0 mg
amphetamine sulfate^[4]		(C₉H₁₃N)₂•H₂SO₄	368.49	270.41	73.38%	36.69%	36.69%	11.0 mg	11.0 mg	30.0 mg
Adderall					62.57%	47.49%	15.08%	14.2 mg	4.5 mg	35.2 mg
25%	dextroamphetamine sulfate^[2]^[3]	(C₉H₁₃N)₂•H₂SO₄	368.49	270.41	73.38%	73.38%	—
25%	amphetamine sulfate^[4]	(C₉H₁₃N)₂•H₂SO₄	368.49	270.41	73.38%	36.69%	36.69%
25%	dextroamphetamine saccharate^[5]	(C₉H₁₃N)₂•C₆H₁₀O₈	480.55	270.41	56.27%	56.27%	—
25%	amphetamine aspartate monohydrate^[6]	(C₉H₁₃N)•C₄H₇NO₄•H₂O	286.32	135.21	47.22%	23.61%	23.61%
lisdexamfetamine dimesylate^[7]		C₁₅H₂₅N₃O•(CH₄O₃S)₂	455.49	135.21	29.68%	29.68%	—	8.9 mg	—	74.2 mg
amphetamine base suspension^[8]		C₉H₁₃N	135.21	135.21	100%	76.19%	23.81%	22.9 mg	7.1 mg	22.0 mg

References

^ "Molecular Weight Calculator". Lenntech. Retrieved 19 August 2015.
^ ^a ^b "Dextroamphetamine Sulfate USP". Mallinckrodt Pharmaceuticals. March 2014. Retrieved 19 August 2015.
^ ^a ^b "D-amphetamine sulfate". Tocris. 2015. Retrieved 19 August 2015.
^ ^a ^b "Amphetamine Sulfate USP". Mallinckrodt Pharmaceuticals. March 2014. Retrieved 19 August 2015.
^ "Dextroamphetamine Saccharate". Mallinckrodt Pharmaceuticals. March 2014. Retrieved 19 August 2015.
^ "Amphetamine Aspartate". Mallinckrodt Pharmaceuticals. March 2014. Retrieved 19 August 2015.
^ "Vyvanse Prescribing Information" (PDF). United States Food and Drug Administration. Shire US Inc. May 2017. pp. 17–21. Retrieved 10 July 2017.
^ "Dyanavel XR Prescribing Information" (PDF). United States Food and Drug Administration. Tris Pharma, Inc. May 2017. pp. 1–14. Retrieved 4 August 2017. This product (Dyanavel XR) is an oral suspension (i.e., a drug that is suspended in a liquid and taken by mouth) that contains 2.5 mg/mL of amphetamine base. The amphetamine base contains dextro- to levo-amphetamine in a ratio of 3.2:1, which is approximately the ratio in Adderall. The product uses an ion exchange resin to achieve extended release of the amphetamine base.

^ For uniformity, molar masses were calculated using the Lenntech Molecular Weight Calculator^[1] and were within 0.01 g/mol of published pharmaceutical values.
^ Amphetamine base percentage = molecular mass_base / molecular mass_total. Amphetamine base percentage for Adderall = sum of component percentages / 4.
^ dose = (1 / amphetamine base percentage) × scaling factor = (molecular mass_total / molecular mass_base) × scaling factor. The values in this column were scaled to a 30 mg dose of dextroamphetamine sulfate. Due to pharmacological differences between these medications (e.g., differences in the release, absorption, conversion, concentration, differing effects of enantiomers, half-life, etc.), the listed values should not be considered equipotent doses.