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The Correlation between Relatives on the Supposition of Mendelian Inheritance

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Ronald Fisher in 1912
The Correlation between Relatives on the Supposition of Mendelian Inheritance
AuthorRonald Fisher
LanguageEnglish
SubjectQuantitative genetics
Publication date
1918
Publication placeUnited States

"The Correlation between Relatives on the Supposition of Mendelian Inheritance"[1] is a scientific paper by Ronald Fisher which was published in the Transactions of the Royal Society of Edinburgh in 1918, (volume 52, pages 399–433).

In it, Fisher puts forward the "infinitesimal model", a genetics conceptual model showing that continuous variation amongst phenotypic traits could be the result of Mendelian inheritance. The paper also contains the first use of the statistical term variance.[2] It is considered the foundation of quantitative genetics.[3]

Background

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Karl Pearson

Mendelian inheritance was rediscovered in 1900. However, there were differences of opinion as to the variation that natural selection acted upon. The biometric school, led by Karl Pearson followed Charles Darwin's idea that small differences were important for evolution. The Mendelian school, led by William Bateson, however thought that Gregor Mendel's work gave an evolutionary mechanism with large differences. Joan Box, Fisher's biographer and daughter states in her 1978 book, The Life of a Scientist[4] that Fisher, then a student, had resolved this problem in 1911.

Fisher had originally submitted his paper (then entitled "The correlation to be expected between relatives on the supposition of Mendelian inheritance") to the Royal Society of London, to be published in their Transactions. The two referees, the biologist R. C. Punnett and the statistician Karl Pearson, believed that the paper contained areas they were unable to judge, due to lack of expertise, and expressed some reservations. Though the paper was not rejected, Fisher carried on a feud with Pearson from 1917 onwards, and instead sent the paper via J. Arthur Thomson to the Royal Society of Edinburgh, which published it in its Transactions.

Model

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Fisher defined his new term variance, as the square of the standard deviation, because of the manner in which variances of independent random variables may be added. He noted the continuous variation in human characters.

References

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  1. ^ Fisher, R. A. (1919). "XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance". Transactions of the Royal Society of Edinburgh. 52 (2): 399–433. doi:10.1017/S0080456800012163. ISSN 0080-4568. S2CID 181213898.
  2. ^ Tabery, James (2007). "Biometric and developmental gene–environment interactions: Looking back, moving forward". Development and Psychopathology. 19 (4): 961–976. doi:10.1017/S0954579407000478. ISSN 1469-2198. PMID 17931428. S2CID 412662.
  3. ^ Visscher, Peter M.; Goddard, Michael E. (2019). "From R.A. Fisher's 1918 Paper to GWAS a Century Later". Genetics. 211 (4): 1125–1130. doi:10.1534/genetics.118.301594. ISSN 0016-6731. PMC 6456325. PMID 30967441.
  4. ^ R A Fisher: the life of a scientist Preface

Notes

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