User:Mr. Ibrahem/Clobazam
Clinical data | |
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Pronunciation | kloe' ba zam[1] |
Trade names | Frisium, Urbanol, Onfi, others[1] |
AHFS/Drugs.com | Monograph |
MedlinePlus | a612008 |
License data | |
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Routes of administration | By mouth |
Drug class | Benzodiazepine[1] |
Legal status | |
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Pharmacokinetic data | |
Bioavailability | 87% (by mouth) |
Protein binding | 80–90% |
Metabolism | Liver |
Metabolites |
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Onset of action | 0.5–4 hours |
Elimination half-life |
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Excretion | |
Identifiers | |
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Chemical and physical data | |
Formula | C16H13ClN2O2 |
Molar mass | 300.74 g·mol−1 |
3D model (JSmol) | |
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Clobazam, sold under the brand names Frisium among others, is a medication used to treat anxiety and epilepsy.[2] This includes Lennox-Gastaut and Dravet syndrome.[3] For anxiety it should only be used short term.[2] It is taken by mouth.[2]
Common side effects include sedation, drooling, vomiting, constipation, pneumonia, poor coordination, and appetite change.[3] Other side effects may include misuse, suicide, Stevens-Johnson syndrome, and infertility.[3] Use during pregnancy may harm the baby.[3] It is a benzodiazepine that is believed to work by enhancing gamma-aminobutyric acid (GABA).[1]
Clobazam was patented in 1968 and come into medical use in 1975.[4] It is available as a generic medication.[2] In the United Kingdom 30 pills of 10 mg costs the NHS about £4 as of 2021.[2] This amount in the United States is about 20 USD.[5] In the United States it is a schedule IV controlled substance.[3]
References[edit]
- ^ a b c d "Clobazam". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 5 January 2022.
- ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 355. ISBN 978-0857114105.
- ^ a b c d e f "Clobazam Monograph for Professionals". Drugs.com. Archived from the original on 23 November 2021. Retrieved 5 January 2022.
- ^ "Clobazam (T3D4564)". Toxin and Toxin Target Database (T3DB. Archived from the original on 2020-11-25. Retrieved 2021-09-14.
- ^ "Clobazam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 5 January 2022.