User:Mr. Ibrahem/Dobutamine
Clinical data | |
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Trade names | Dobutrex, Inotrex, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682861 |
License data |
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Pregnancy category |
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Routes of administration | Intravenous, intraosseous[2] |
Drug class | β1-agonist |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Onset of action | Within 2 min[2] |
Elimination half-life | 2 minutes |
Identifiers | |
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Chemical and physical data | |
Formula | C18H23NO3 |
Molar mass | 301.386 g·mol−1 |
3D model (JSmol) | |
Chirality | Racemic mixture |
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Dobutamine is a medication used in the treatment of cardiogenic shock and severe heart failure.[2][4] It may also be used in certain types of cardiac stress tests.[2] It is given by injection into a vein or intraosseous as a continuous infusion.[2] The amount of medication needs to be adjusted to the desired effect.[2] Onset of effects is generally seen within 2 minutes.[2]
Common side effects include a fast heart rate, an irregular heart beat, and inflammation at the site of injection.[2][5] Use is not recommended in those with idiopathic hypertrophic subaortic stenosis.[2] It primarily works by direct stimulation of β1 receptors, which increases the strength of the heart's contractions.[2] Generally it has little effect on a person's heart rate.[2]
Dobutamine was approved for medical use in the United States in 1978.[2] It is available as a generic medication.[5] In the United Kingdom as of 2018 it costs the NHS about 2 pounds per vial.[5] It was initially made from isoproterenol.[4]
References[edit]
- ^ a b "Dobutamine (Dobutrex) Use During Pregnancy". Drugs.com. 18 March 2020. Retrieved 17 May 2020.
- ^ a b c d e f g h i j k l "Dobutamine Hydrochloride Monograph for Professionals". Drugs.com. AHFS. Retrieved 11 January 2019.
- ^ Cite error: The named reference
WHO2020DDD
was invoked but never defined (see the help page). - ^ a b Wilson, William C.; Grande, Christopher M.; Hoyt, David B. (2007). Trauma: Critical Care. CRC Press. p. 302. ISBN 9781420016840.
- ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 220–221. ISBN 9780857113382.