User:Mr. Ibrahem/Etodolac
Clinical data | |
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Trade names | Etolyn, Etopan, Lodine, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692015 |
Pregnancy category |
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Routes of administration | By mouth |
Drug class | Nonsteroidal anti-inflammatory drug (NSAID)[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Protein binding | 100% |
Metabolism | liver |
Elimination half-life | 7.3 ± 4.0 hours |
Excretion | renal |
Identifiers | |
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Chemical and physical data | |
Formula | C17H21NO3 |
Molar mass | 287.359 g·mol−1 |
3D model (JSmol) | |
Melting point | 145 to 148 °C (293 to 298 °F) |
Solubility in water | 3.92e-02 mg/mL [ALOGPS] mg/mL (20 °C) |
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Etodolac, sold under the brand name Etolyn among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation.[2] This may include in conditions such as osteoarthritis or rheumatic arthritis.[2] It is taken by mouth.[2]
Common side effects include heart burn, abdominal pain, GI bleeding, nausea, kidney problems, dizziness, swelling, bleeding, ringing in the ears, and liver problems.[1] Other side effects may include heart attacks, high blood pressure, heart failure, and anaphylaxis.[1] Use in the later half of pregnancy may harm the baby.[1] It works by blocking COX1 and COX2.[1]
Etodolac was patented in 1971 and approved for medical use in 1985.[3] It was approved in the U.S. in 1991.[1] It is available as a generic medication.[4] In the United Kingdom 30 tablets of 600 mg costs the NHS about £15 as of 2021.[2] This amount in the United States costs about 22 USD.[4]
References[edit]
- ^ a b c d e f g "Etodolac Monograph for Professionals". Drugs.com. Archived from the original on 28 August 2021. Retrieved 16 December 2021.
- ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1184. ISBN 978-0857114105.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 517. ISBN 9783527607495. Archived from the original on 2021-07-26. Retrieved 2020-12-29.
- ^ a b "Etodolac Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 16 December 2021.