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A 2012 meta-analysis showed that prostaglandin inhibitors and calcium channel blockers had the most effective tocolytic therapy at delaying delivery and improving neonatal mortality and maternal outcomes when comparing with the top three medication classes, beta mimetics, magnesium sulfate, and calcium channel blockers.[1]
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- ^ Haas, David M.; Caldwell, Deborah M.; Kirkpatrick, Page; McIntosh, Jennifer J.; Welton, Nicky J. (2012). "Tocolytic therapy for preterm delivery: systematic review and network meta-analysis". BMJ (Clinical research ed.). 345: e6226. doi:10.1136/bmj.e6226. ISSN 1756-1833. PMC 4688428. PMID 23048010.
Indication[edit]
Tocolytics are used in preterm labor, which refers to when a baby is born too early before 37 weeks of pregnancy. The goal is to reduce neonatal morbidity and mortality through delaying delivery and increasing gestational age by gaining more time for corticosteroids therapy as preterm birth represents one of the leading cause of neonatal morbidity and mortality.[1][2]
- ^ Ouzounian, Joseph G; Goodwin, T. Murphy; Paulson, Richard J; Montoro, Martin N; Muderspach, Laila I; Roy, Subir (2010). Management of Common Problems in Obstetrics and Gynecology. Blackwell Publishing Ltd. pp. 9–11. ISBN 9781444323030.
- ^ Harrison, Margo S.; Goldenberg, Robert L. (2016). "Global burden of prematurity". Seminars in Fetal & Neonatal Medicine. 21 (2): 74–79. doi:10.1016/j.siny.2015.12.007. ISSN 1878-0946. PMID 26740166.