ZD-9379
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| IUPAC name
7-Chloro-2-(4-methoxy-2-methylphenyl)-3,5-dihydropyridazino[4,5-b]quinoline-1,4,10-trione
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| Identifiers | |
3D model (JSmol)
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| ChEMBL | |
| ChemSpider | |
PubChem CID
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| Properties | |
| C19H14ClN3O4 | |
| Molar mass | 383.79 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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ZD-9379 is an antagonist of the N-methyl-D-aspartate receptor. It possesses neuroprotective properties and could potentially be used for the treatment of certain strokes.
Mechanism of action
[edit]ZD-9379 works by antagonizing (blocking) the glycine site on the NMDA receptor,[1][2] because both glycine (co-agonist) and an agonist at the main site are needed to activate the NMDA receptor, blocking the glycine binding site prevents the receptor from activating.
Potential use
[edit]In rats, ZD-9379 has been tested to help spreading depression and brain infarction, results have shown that treatment with ZD-9379 reduced the amount of spreading depressions and the volume of infarcts.[3] Another study was also able to produce similar results.[4]
References
[edit]- ^ "ZD 9379 | CAS 170142-20-8 | ZD9379 | Tocris Bioscience".
- ^ Danysz, Wojciech; Parsons, Chris G. (March 2002). "Neuroprotective potential of ionotropic glutamate receptor antagonists". Neurotoxicity Research. 4 (2): 119–126. doi:10.1080/10298420290015872. ISSN 1476-3524. PMID 12829411.
- ^ Tatlisumak, T.; Takano, K.; Meiler, M. R.; Fisher, M. (2000). "A glycine site antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion". Acta Neurochirurgica. Supplement. 76: 331–333. doi:10.1007/978-3-7091-6346-7_68. ISSN 0065-1419. PMID 11450037.
- ^ Qiu, H.; Hedlund, L. W.; Gewalt, S. L.; Benveniste, H.; Bare, T. M.; Johnson, G. A. (1997). "Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/NMDA antagonist: an in vivo three-dimensional diffusion-weighted MR microscopy study". Journal of magnetic resonance imaging: JMRI. 7 (4): 739–744. doi:10.1002/jmri.1880070421. ISSN 1053-1807. PMID 9243396.