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Chemical compound
Abediterol Routes of administration Inhalation ATC code Elimination half-life 24.3 hours[1]
5-[(1R )-2-{[6-(2,2-Difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl]-8-hydroxyquinolin-2(1H )-one
CAS Number PubChem CID IUPHAR/BPS ChemSpider UNII KEGG ChEBI ChEMBL CompTox Dashboard (EPA ) Formula C 25 H 30 F 2 N 2 O 4 Molar mass 460.522 g·mol−1 3D model (JSmol )
FC(F)(c1ccccc1)COCCCCCCNC[C@H](O)c3ccc(O)c2c3\C=C/C(=O)N2
InChI=1S/C25H30F2N2O4/c26-25(27,18-8-4-3-5-9-18)17-33-15-7-2-1-6-14-28-16-22(31)19-10-12-21(30)24-20(19)11-13-23(32)29-24/h3-5,8-13,22,28,30-31H,1-2,6-7,14-17H2,(H,29,32)/t22-/m0/s1
Y Key:SFYAXIFVXBKRPK-QFIPXVFZSA-N
Y
Abediterol (INN ;[2] development codes AZD-0548 and LAS 100977) is a once-daily experimental drug candidate for the treatment of asthma and chronic obstructive pulmonary disease (COPD), but it has never been marketed.
History [ edit ]
Abediterol was under development by the Spanish pharmaceutical company Almirall and reached Phase II clinical trials,[3] [4] but was discontinued in 2021.[5] Its coformulation with mometasone furoate also progressed to Phase II clinical trials, but was discontinued in 2019.[6]
Mechanism of action [ edit ]
Abediterol acts as a dual β2 adrenergic agonist [7] [8] and muscarinic antagonist and is classified as an ultra-long-acting β2 agonist (ultra-LABA).[9]
References [ edit ]
^ Timmer W, Massana E, Jimenez E, Seoane B, de Miquel G, Ruiz S (December 2014). "First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of abediterol (LAS100977), a novel long-acting Β2 -agonist". Journal of Clinical Pharmacology . 54 (12): 1347–53. doi :10.1002/jcph.355 . PMID 24989946 . S2CID 20959248 .
^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed International Nonproprietary Names: List 104" (PDF) . WHO Drug Information . 24 (1): 352. 2010. Retrieved 25 March 2016 .
^ Product development pipeline , Almirall
^ "AdisInsight: Abediterol" . Adis Insight . Springer International Publishing AG. Retrieved 25 March 2016 .
^ "Abediterol" . Adis Insight . Springer International Publishing AG. Retrieved 6 February 2024 .
^ "AdisInsight: Abediterol/mometasone" . Adis Insight . Springer International Publishing AG. Retrieved 6 February 2024 .
^ "Espacenet - Bibliographic data" . worldwide.espacenet.com . Retrieved 2021-05-07 .
^ "Espacenet - Bibliographic data" . worldwide.espacenet.com . Retrieved 2021-05-07 .
^ Beier J, Fuhr R, Massana E, Jiménez E, Seoane B, de Miquel G, Ruiz S (October 2014). "Abediterol (LAS100977), a novel long-acting β2-agonist: efficacy, safety and tolerability in persistent asthma" . Respiratory Medicine . 108 (10): 1424–9. doi :10.1016/j.rmed.2014.08.005 . PMID 25256258 .
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