DUSP19

DUSP19
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3S4E, 4D3P, 4D3R, 4D3Q
Identifiers
Aliases	DUSP19, DUSP17, LMWDSP3, SKRP1, TS-DSP1, dual specificity phosphatase 19
External IDs	OMIM: 611437; MGI: 1915332; HomoloGene: 41565; GeneCards: DUSP19; OMA:DUSP19 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q32.1 Start 183,078,559 bp End 183,100,008 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 C3 Start 80,447,389 bp End 80,462,705 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte buccal mucosa cell gonad bronchial epithelial cell testicle islet of Langerhans Descending thoracic aorta mucosa of paranasal sinus ventricular zone Top expressed in medullary collecting duct condyle endocardial cushion Paneth cell lumbar subsegment of spinal cord endothelial cell of lymphatic vessel sternocleidomastoid muscle fossa right ventricle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity MAP-kinase scaffold activity mitogen-activated protein kinase kinase kinase binding phosphatase activity protein kinase inhibitor activity protein kinase activator activity protein binding protein tyrosine phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity JUN kinase phosphatase activity Cellular component cytoplasm Biological process negative regulation of protein kinase activity positive regulation of JUN kinase activity protein dephosphorylation positive regulation of JNK cascade negative regulation of JNK cascade peptidyl-tyrosine dephosphorylation negative regulation of JUN kinase activity positive regulation of MAPK cascade positive regulation of protein kinase activity dephosphorylation activation of protein kinase activity regulation of MAP kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 142679 68082 Ensembl ENSG00000162999 ENSMUSG00000027001 UniProt Q8WTR2 Q8K4T5 Q99N12 RefSeq (mRNA) NM_001142314 NM_080876 NM_001321519 NM_024438 RefSeq (protein) NP_001135786 NP_001308448 NP_543152 NP_077758 Location (UCSC) Chr 2: 183.08 – 183.1 Mb Chr 2: 80.45 – 80.46 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP19 gene.

Interactions

DUSP19 has been shown to interact with ASK1 and MAP2K7.

Further reading

• Cheng H, Gao Q, Jiang M, Ma Y, Ni X, Guo L, Jin W, Cao G, Ji C, Ying K, Xu W, Gu S, Ma Y, Xie Y, Mao Y (February 2003). "Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3". The International Journal of Biochemistry & Cell Biology. 35 (2): 226–34. doi:10.1016/S1357-2725(02)00127-9. PMID 12479873.
• Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M (June 2002). "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway". The Journal of Biological Chemistry. 277 (26): 23919–26. doi:10.1074/jbc.M200838200. PMID 11959862.
• Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M (June 2002). "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway". The Journal of Biological Chemistry. 277 (26): 23909–18. doi:10.1074/jbc.M200837200. PMID 11959861.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8WTR2 (Human Dual specificity protein phosphatase 19 (DUSP19)) at the PDBe-KB.