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Sex-hormonal agent

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Sex-hormonal agent
Drug class
Class identifiers
SynonymsSex-steroidal agent; Sex-hormone receptor modulator
UseHormone therapy; Antihormone therapy; Hormonal contraception
Biological targetAndrogen receptor; Estrogen receptor; Progesterone receptor
Chemical classSteroidal; Nonsteroidal
Legal status
In Wikidata

A sex-hormonal agent, also known as a sex-hormone receptor modulator, is a type of hormonal agent which specifically modulates the effects of sex hormones and of their biological targets, the sex hormone receptors. The sex hormones include androgens such as testosterone, estrogens such as estradiol, and progestogens such as progesterone.[1] Sex-hormonal agents may be either steroidal or nonsteroidal in chemical structure and may serve to either enhance, inhibit, or have mixed effects on the function of the sex hormone systems.[2]

Sex-hormonal agents are used in medicine for a variety of purposes including hormone therapy (e.g., menopausal hormone therapy, androgen replacement therapy, transgender hormone therapy), antihormone therapy (e.g., androgen deprivation therapy, estrogen deprivation therapy), and hormonal contraception, among others.

Types and examples

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Androgen receptor (AR) modulators

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See also: Androgen receptor

Estrogen receptor (ER) modulators

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See also: Estrogen receptor

Progesterone receptor (PR) modulators

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See also: Progesterone receptor

Indirect sex-hormonal agents

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Drugs that indirectly influence sex hormone systems, such as antigonadotropins like GnRH analogues and prolactin releasers (e.g., D2 receptor antagonists), progonadotropins like GnRH agonists, and steroidogenesis inhibitors like aromatase inhibitors and androgen synthesis inhibitors, are also sex-hormonal agents.

See also

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References

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  1. ^ Thomas L. Lemke; David A. Williams (2008). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 1266–1267. ISBN 978-0-7817-6879-5.
  2. ^ Judi Lindsley Nath (2006). Using Medical Terminology: A Practical Approach. Lippincott Williams & Wilkins. pp. 977–. ISBN 978-0-7817-4868-1.


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