GPR124

ADGRA2
Identifiers
Aliases	ADGRA2, G protein-coupled receptor 124, TEM5, GPR124, adhesion G protein-coupled receptor A2
External IDs	OMIM: 606823; MGI: 1925810; HomoloGene: 13112; GeneCards: ADGRA2; OMA:ADGRA2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	37,844,896 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	27,613,464 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; seminal vesicula; ; canal of the cervix; ; left uterine tube; ; saphenous vein; ; body of uterus; ; gallbladder; ; right ovary; ; tail of epididymis; ; superficial temporal artery;
	Top expressed in
	umbilical cord; ; dermis; ; external carotid artery; ; Gonadal ridge; ; yolk sac; ; endocardial cushion; ; internal carotid artery; ; vas deferens; ; uterus; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; signal transducer activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; membrane; cell projection; filopodium;
Biological process	positive regulation of endothelial cell migration; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; central nervous system development; negative regulation of vascular endothelial growth factor signaling pathway; sprouting angiogenesis; regulation of angiogenesis; endothelial cell migration; regulation of chemotaxis; angiogenesis; signal transduction; regulation of establishment of blood-brain barrier;
	Sources:Amigo / QuickGO
Orthologs
	25960
	78560
	ENSG00000020181
	ENSMUSG00000031486
	Q96PE1
	Q91ZV8
	NM_032777
	NM_054044
	NP_116166
	NP_473385
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.^[5]^[6]^[7] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[8]^[9]^[10]

Interactions

GPR124 has been shown to interact with DLG1^[11] and is involved in the Wnt/β-catenin signaling pathway along with RECK.^[12] GPR124 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of GPR124 by these viral proteases may be important for entry into the brain.^[13] GPR124 (ADGRA2) was predicted using SSHHPS.

Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000020181 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031486 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Research. 61 (18): 6649–6655. PMID 11559528.
^ Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB (February 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochemical and Biophysical Research Communications. 301 (3): 725–734. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
^ "Entrez Gene: GPR124 G protein-coupled receptor 124".
^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
^ Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y (May 2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene. 23 (22): 3889–3897. doi:10.1038/sj.onc.1207495. PMID 15021905. S2CID 6082566.
^ Vanhollebeke B, Stone OA, Bostaille N, Cho C, Zhou Y, Maquet E, et al. (June 2015). Rossant J (ed.). "Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis". eLife. 4: e06489. doi:10.7554/eLife.06489. PMC 4456509. PMID 26051822.
^ Doctor KZ, Gilmour E, Recarte M, Beatty TR, Shifa I, Stangel M, et al. (February 2023). "Automated SSHHPS Analysis Predicts a Potential Host Protein Target Common to Several Neuroinvasive (+)ssRNA Viruses". Viruses. 15 (2): 542. doi:10.3390/v15020542. PMC 9961674. PMID 36851756.

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–150. doi:10.1093/dnares/7.2.143. PMID 10819331.
Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y (May 2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene. 23 (22): 3889–3897. doi:10.1038/sj.onc.1207495. PMID 15021905. S2CID 6082566.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Vallon M, Essler M (November 2006). "Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans". The Journal of Biological Chemistry. 281 (45): 34179–34188. doi:10.1074/jbc.M605291200. PMID 16982628.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000020181 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031486 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11559528-5] Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Research. 61 (18): 6649–6655. PMID 11559528.

[pmid12565841-6] Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB (February 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochemical and Biophysical Research Communications. 301 (3): 725–734. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.

[entrez-7] "Entrez Gene: GPR124 G protein-coupled receptor 124".

[isbn1-4419-7912-3-8] Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[pmid12435584-9] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[pmid22333914-10] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[pmid15021905-11] Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y (May 2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene. 23 (22): 3889–3897. doi:10.1038/sj.onc.1207495. PMID 15021905. S2CID 6082566.

[12] Vanhollebeke B, Stone OA, Bostaille N, Cho C, Zhou Y, Maquet E, et al. (June 2015). Rossant J (ed.). "Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis". eLife. 4: e06489. doi:10.7554/eLife.06489. PMC 4456509. PMID 26051822.

[13] Doctor KZ, Gilmour E, Recarte M, Beatty TR, Shifa I, Stangel M, et al. (February 2023). "Automated SSHHPS Analysis Predicts a Potential Host Protein Target Common to Several Neuroinvasive (+)ssRNA Viruses". Viruses. 15 (2): 542. doi:10.3390/v15020542. PMC 9961674. PMID 36851756.

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Interactions

References

Further reading