GPR133

ADGRD1
Identifiers
Aliases	ADGRD1, PGR25, GPR133, adhesion G protein-coupled receptor D1
External IDs	OMIM: 613639; MGI: 3041203; HomoloGene: 34616; GeneCards: ADGRD1; OMA:ADGRD1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	131,141,469 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	129,281,663 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; right auricle; ; tibial nerve; ; decidua; ; right lung; ; sural nerve; ; upper lobe of left lung; ; myocardium of left ventricle; ; gastric mucosa; ; apex of heart;
	Top expressed in
	lumbar spinal ganglion; ; Ileal epithelium; ; lactiferous gland; ; ankle joint; ; extraocular muscle; ; white adipose tissue; ; body of femur; ; sciatic nerve; ; ascending aorta; ; thoracic diaphragm;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane; intracellular anatomical structure; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	283383
	243277
	ENSG00000111452
	ENSMUSG00000044017
	Q6QNK2
	Q80T32
	NM_198827; NM_001330497
	NM_001081342; NM_177734; NM_001347486
	NP_001317426; NP_942122
	NP_001074811; NP_001334415
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.^[5]^[6]

This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111452 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044017 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GPR133 G protein-coupled receptor 133".
^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

Vanti WB, Nguyen T, Cheng R, et al. (2003). "Novel human G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 305 (1): 67–71. doi:10.1016/S0006-291X(03)00709-5. PMID 12732197.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111452 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044017 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GPR133 G protein-coupled receptor 133".

[pmid12435584-6] Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[isbn1-4419-7912-3-7] Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[pmid22333914-8] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

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References

Further reading