GPR45

GPR45
Identifiers
Aliases	GPR45, PSP24, PSP24(ALPHA), PSP24A, G protein-coupled receptor 45
External IDs	OMIM: 604838; MGI: 2135882; HomoloGene: 5228; GeneCards: GPR45; OMA:GPR45 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	105,243,467 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	43,074,616 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; Hypothalamus; ; nucleus accumbens; ; Amygdala; ; embryo; ; caudate nucleus;
	Top expressed in
	lumbar subsegment of spinal cord; ; ventricular zone; ; ganglionic eminence; ; arcuate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; paraventricular nucleus of hypothalamus; ; primary visual cortex; ; dorsomedial hypothalamic nucleus; ; superior frontal gyrus; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	11250
	93690
	ENSG00000135973
	ENSMUSG00000041907
	Q9Y5Y3
	Q9EQQ4
	NM_007227
	NM_053107
	NP_009158
	NP_444337
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.^[5]^[6]

This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135973 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041907 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.
^ ^a ^b "Entrez Gene: GPR45 G protein-coupled receptor 45".

Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.
Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135973 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041907 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10036181-5] Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.

[entrez-6] "Entrez Gene: GPR45 G protein-coupled receptor 45".

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References

Further reading